4NCS
Human sialidase 2 in complex with 2,3-difluorosialic acid (covalent intermediate)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Sialidase-2 | polymer | 382 | 42375.6 | 1 | UniProt (Q9Y3R4) Pfam (PF13088) In PDB | Homo sapiens (human) | Cytosolic sialidase, N-acetyl-alpha-neuraminidase 2 |
2 | A | (2S,3S,4R,5R,6R)-5-acetamido-2,3-bis(fluoranyl)-4-oxidanyl-6-[(1S,2S)-1,2,3-tris(oxidanyl)propyl]oxane-2-carboxylic acid | non-polymer | 329.3 | 1 | Chemie (FSR) | |||
3 | A | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
4 | water | water | 18.0 | 212 | Chemie (HOH) |
Sequence modifications
A: 1 - 380 (UniProt: Q9Y3R4)
PDB | External Database | Details |
---|---|---|
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
Ala 46 | Asp 46 | engineered mutation |
Asn 168 | His 168 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 42375.6 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 519.2 | |
All* | Total formula weight | 42894.8 |