4N86

Crystal structure of human transthyretin complexed with glabridin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Transthyretin	polymer	159	17310.5	2	UniProt (P02766) Pfam (PF00576) In PDB	Homo sapiens (human)	ATTR, Prealbumin, TBPA
2	A, B	4-[(3R)-8,8-dimethyl-3,4-dihydro-2H,8H-pyrano[2,3-f]chromen-3-yl]benzene-1,3-diol	non-polymer		324.4	2	Chemie (GBJ)
3	A	CALCIUM ION	non-polymer		40.1	1	Chemie (CA)
4		water	water		18.0	76	Chemie (HOH)

Sequence modifications

A, B: -19 - 127 (UniProt: P02766)

PDB	External Database	Details
Met -31	-	expression tag
Arg -30	-	expression tag
Gly -29	-	expression tag
Ser -28	-	expression tag
His -27	-	expression tag
His -26	-	expression tag
His -25	-	expression tag
His -24	-	expression tag
His -23	-	expression tag
His -22	-	expression tag
Gly -21	-	expression tag
Ser -20	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	34621.0
Non-Polymers*	Number of molecules	3
	Total formula weight	688.8
All*	Total formula weight	35309.9

*Water molecules are not included.