4N86

Crystal structure of human transthyretin complexed with glabridin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0042572	biological_process	retinol metabolic process
A	0070324	molecular_function	thyroid hormone binding
A	0070327	biological_process	thyroid hormone transport
B	0042572	biological_process	retinol metabolic process
B	0070324	molecular_function	thyroid hormone binding
B	0070327	biological_process	thyroid hormone transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GBJ A 201

Chain	Residue
A	LYS15
A	LYS15
A	LEU17
A	LEU17
A	ALA108
A	ALA109
A	LEU110
A	LEU110
A	SER117

---

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA A 202

Chain	Residue
A	GLU66
A	ASP99

---

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GBJ B 201

Chain	Residue
B	LYS15
B	LYS15
B	LEU17
B	LEU17
B	ALA108
B	ALA109
B	LEU110
B	LEU110
B	SER117
B	SER117

---

Functional Information from PROSITE/UniProt

site_id	PS00768
Number of Residues	16
Details	TRANSTHYRETIN_1 Transthyretin signature 1. KVLDavrGsPAinVaV

Chain	Residue	Details
A	LYS15-VAL30

---

site_id	PS00769
Number of Residues	13
Details	TRANSTHYRETIN_2 Transthyretin signature 2. YTIAalLSPYSYS

Chain	Residue	Details
A	TYR105-SER117

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:11418763, ECO:0007744|PDB:1ICT

Chain	Residue	Details
A	LYS15
A	GLU54
A	SER117
B	LYS15
B	GLU54
B	SER117

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Sulfocysteine => ECO:0000269|PubMed:17175208, ECO:0007744|PDB:2H4E

Chain	Residue	Details
A	CYS10
B	CYS10

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: 4-carboxyglutamate; in a patient with Moyamoya disease => ECO:0000269|PubMed:18221012

Chain	Residue	Details
A	GLU42
B	GLU42

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P02767

Chain	Residue	Details
A	SER52
B	SER52

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19167329

Chain	Residue	Details
A	ASN98
B	ASN98

---