4N07
Crystal structure of the GluA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and BPAM-344 at 1.87 A resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Glutamate receptor 2 | polymer | 263 | 29244.7 | 3 | UniProt (P19491) Pfam (PF10613) Pfam (PF00060) | Rattus norvegicus (rat) | GluR-2, AMPA-selective glutamate receptor 2, GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA 2, GluA2 |
| 2 | D, DA, U (A, C, B) | 4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide | non-polymer | 242.3 | 3 | Chemie (2J9) | |||
| 3 | E, EA, V (A, C, B) | GLUTAMIC ACID | non-polymer | 147.1 | 3 | Chemie (GLU) | |||
| 4 | F, FA, G, GA, H... (A, C, B) | ACETATE ION | non-polymer | 59.0 | 13 | Chemie (ACT) | |||
| 5 | AA, KA, L, LA, M... (B, C, A) | ZINC ION | non-polymer | 65.4 | 10 | Chemie (ZN) | |||
| 6 | P (A) | CACODYLATE ION | non-polymer | 137.0 | 1 | Chemie (CAC) | |||
| 7 | BA, CA, Q, R, S... (B, A) | GLYCEROL | non-polymer | 92.1 | 6 | Chemie (GOL) | |||
| 8 | NA, OA, PA (A, B, C) | water | water | 18.0 | 687 | Chemie (HOH) |
Sequence modifications
A, B, C: 3 - 117 (UniProt: P19491)
A, B, C: 120 - 263 (UniProt: P19491)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
| Ala 2 | - | expression tag |
| Tyr 94 | Leu 504 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 118 | - | linker |
| Thr 119 | - | linker |
| Ser 242 | Asn 775 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 87734.0 | |
| Non-Polymers* | Number of molecules | 36 |
| Total formula weight | 3279.4 | |
| All* | Total formula weight | 91013.4 |
