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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4N07

Crystal structure of the GluA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and BPAM-344 at 1.87 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 2J9 A 301

Chain	Residue
A	LYS104
A	GLY219
A	SER242
A	PRO105
A	PRO105
A	PHE106
A	MET107
A	SER108
A	SER108
A	SER217
A	LYS218

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE GLU A 302

Chain	Residue
A	TYR61
A	PRO89
A	LEU90
A	THR91
A	ARG96
A	GLY141
A	SER142
A	THR143
A	GLU193
A	HOH401
A	HOH404
A	HOH412

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT A 303

Chain	Residue
A	ARG180
A	SER184
A	LYS187
A	TYR188

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT A 304

Chain	Residue
A	ASN214
A	ASP216
A	ASP248

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT A 305

Chain	Residue
A	LYS144
A	PHE170
A	ZN311
A	CAC313

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT A 306

Chain	Residue
A	LYS20
A	HIS23
A	GLU30
A	ZN309
C	HIS23
C	HOH500

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT A 307

Chain	Residue
A	LYS204
A	GLU260
A	HOH663

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACT A 308

Chain	Residue
A	LYS4
A	ASP84

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 309

Chain	Residue
A	HIS23
A	GLU30
A	ACT306
C	HIS23

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN A 310

Chain	Residue
A	ASP156
A	HOH618

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 311

Chain	Residue
A	ACT305
A	CAC313
A	HOH623
A	HOH655

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 312

Chain	Residue
A	GLU42
A	HIS46
A	LEU241
A	HOH659
B	GLU166

site_id	BC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE CAC A 313

Chain	Residue
A	ARG163
A	ALA165
A	GLU166
A	SER168
A	ACT305
A	ZN311
A	HOH655
B	GLU42
B	HIS46
B	ZN305

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 314

Chain	Residue
A	LEU127
A	SER128
A	GLN130
A	TYR135

site_id	BC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 315

Chain	Residue
A	PRO120
A	GLU132
A	ILE133
A	GLY186
A	LYS187
A	HOH514
A	HOH650

site_id	BC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 316

Chain	Residue
A	GLU201
A	LYS210
A	HOH653

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 317

Chain	Residue
A	GLU122
A	SER123
A	ASP126
A	HOH613
A	HOH664

site_id	BC9
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 2J9 B 301

Chain	Residue
C	SER108
C	SER242
C	LEU247
C	2J9301
B	PRO105
B	MET107
B	SER108
B	SER217
B	LYS218
B	GLY219
C	LYS104
C	PRO105
C	PHE106
C	MET107

site_id	CC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GLU B 302

Chain	Residue
B	TYR61
B	PRO89
B	LEU90
B	THR91
B	ARG96
B	LEU138
B	GLY141
B	SER142
B	THR143
B	GLU193
B	HOH404
B	HOH418
B	HOH500

site_id	CC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT B 303

Chain	Residue
B	MET19
B	HIS23
B	ZN306
C	ASP65
C	ASP67
C	THR68

site_id	CC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT B 304

Chain	Residue
B	ARG180
B	LYS187
B	TYR188

site_id	CC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 305

Chain	Residue
A	GLU166
A	CAC313
B	GLU42
B	HIS46

site_id	CC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 306

Chain	Residue
B	HIS23
B	ACT303
B	HOH540
C	ASP65

site_id	CC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN B 307

Chain	Residue
B	ASP156
B	ARG163

site_id	CC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL B 308

Chain	Residue
B	ASP248
C	ASN214

site_id	CC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL B 309

Chain	Residue
B	GLU201
B	LYS210

site_id	CC9
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 2J9 C 301

Chain	Residue
B	LYS104
B	PRO105
B	PHE106
B	MET107
B	SER108
B	SER242
B	LEU247
B	2J9301
C	PRO105
C	MET107
C	SER108
C	SER217
C	LYS218
C	GLY219

site_id	DC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE GLU C 302

Chain	Residue
C	TYR61
C	PRO89
C	LEU90
C	THR91
C	ARG96
C	LEU138
C	GLY141
C	SER142
C	THR143
C	GLU193
C	TYR220
C	HOH407
C	HOH419
C	HOH495

site_id	DC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT C 303

Chain	Residue
C	GLY62
C	THR93
C	ARG96
C	ARG149
C	HOH455
C	HOH557

site_id	DC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE ACT C 304

Chain	Residue
C	GLU201

site_id	DC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ACT C 305

Chain	Residue
C	GLU42
C	LYS45
C	HIS46
C	ZN308
C	HOH525
C	HOH586
C	HOH603

site_id	DC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACT C 306

Chain	Residue
B	ASN214
C	ASP248

site_id	DC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ACT C 307

Chain	Residue
B	GLU24
C	ALA63
C	ARG64
C	ASN72
C	ASP139
C	SER140
C	ZN310

site_id	DC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 308

Chain	Residue
C	GLU42
C	HIS46
C	ACT305
C	HOH603

site_id	DC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN C 309

Chain	Residue
C	ASP156
C	HOH544
C	HOH556

site_id	DC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN C 310

Chain	Residue
B	GLU24
C	ASP139
C	SER140
C	ACT307
C	HOH574

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	9
Details	BINDING: BINDING => ECO:0000269\|PubMed:16483599

Chain	Residue	Details
B	TYR61
B	ARG96
B	GLU193
C	TYR61
C	ARG96
C	GLU193
A	GLU193
A	TYR61
A	ARG96

site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING:

Chain	Residue	Details
B	PRO89
C	PRO89
A	PRO89

site_id	SWS_FT_FI3
Number of Residues	9
Details	BINDING: BINDING => ECO:0000269\|PubMed:25103405

Chain	Residue	Details
C	THR91
C	SER142
C	THR143
A	THR143
B	THR91
B	SER142
B	THR143
A	THR91
A	SER142

site_id	SWS_FT_FI4
Number of Residues	9
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269\|PubMed:25103405

Chain	Residue	Details
A	ARG64
A	ARG148
A	LYS240
B	ARG64
B	ARG148
B	LYS240
C	ARG64
C	ARG148
C	LYS240

site_id	SWS_FT_FI5
Number of Residues	3
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269\|PubMed:25103405

Chain	Residue	Details
A	ILE121
B	ILE121
C	ILE121

site_id	SWS_FT_FI6
Number of Residues	3
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269\|PubMed:8848293

Chain	Residue	Details
A	SER150
B	SER150
C	SER150

site_id	SWS_FT_FI7
Number of Residues	3
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269\|PubMed:8848293

Chain	Residue	Details
A	SER184
B	SER184
C	SER184

site_id	SWS_FT_FI8
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN3
B	ASN3
C	ASN3

220472

PDB entries from 2024-05-29

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