4MZI
Crystal structure of a human mutant p53
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cellular tumor antigen p53 | polymer | 200 | 22529.6 | 1 | UniProt (P04637) Pfam (PF00870) | Homo sapiens (human) | Antigen NY-CO-13, Phosphoprotein p53, Tumor suppressor p53 |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C (A) | water | water | 18.0 | 214 | Chemie (HOH) |
Sequence modifications
A: 94 - 292 (UniProt: P04637)
| PDB | External Database | Details |
|---|---|---|
| Met 93 | - | initiating methionine |
| Phe 121 | Ser 121 | engineered mutation |
| Gly 122 | Val 122 | engineered mutation |
| Val 135 | Cys 135 | conflict |
| Val 141 | Cys 141 | conflict |
| Tyr 146 | Trp 146 | conflict |
| Ser 182 | Cys 182 | variant |
| Ala 203 | Val 203 | variant |
| Pro 209 | Arg 209 | conflict |
| Tyr 229 | Cys 229 | variant |
| Tyr 233 | His 233 | variant |
| Phe 234 | Tyr 234 | variant |
| Lys 235 | Asn 235 | conflict |
| Phe 236 | Tyr 236 | variant |
| Val 253 | Thr 253 | conflict |
| Asp 268 | Asn 268 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 22529.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 65.4 | |
| All* | Total formula weight | 22595.0 |
