4MZG

Crystal structure of human Spindlin1 bound to histone H3K4me3 peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Peptide from Histone H3.2	polymer	20	2232.7	2	UniProt (Q71DI3)	Homo sapiens	Histone H3/m, Histone H3/o
2	B, D (B, D)	Spindlin-1	polymer	222	25509.7	2	UniProt (Q9Y657) Pfam (PF02513)	Homo sapiens (human)	SP1, Ovarian cancer-related protein
3	E (B)	(4R)-2-METHYLPENTANE-2,4-DIOL	non-polymer		118.2	1	Chemie (MRD)
4	F, I, J (B, D)	(4S)-2-METHYL-2,4-PENTANEDIOL	non-polymer		118.2	3	Chemie (MPD)
5	G (B)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
6	H, K, L (B, D)	CHLORIDE ION	non-polymer		35.5	3	Chemie (CL)
7	M, N, O, P (A, B, C, D)	water	water		18.0	360	Chemie (HOH)

Sequence modifications

B, D: 50 - 262 (UniProt: Q9Y657)

PDB	External Database	Details
His 41	-	EXPRESSION TAG
His 42	-	EXPRESSION TAG
His 43	-	EXPRESSION TAG
His 44	-	EXPRESSION TAG
His 45	-	EXPRESSION TAG
His 46	-	EXPRESSION TAG
Gly 47	-	EXPRESSION TAG
Ser 48	-	EXPRESSION TAG
Met 49	-	EXPRESSION TAG

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	55484.8
Non-Polymers*	Number of molecules	8
	Total formula weight	603.4
All*	Total formula weight	56088.2

*Water molecules are not included.