4MZG
Crystal structure of human Spindlin1 bound to histone H3K4me3 peptide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000786 | cellular_component | nucleosome |
| A | 0003677 | molecular_function | DNA binding |
| A | 0030527 | molecular_function | structural constituent of chromatin |
| B | 0007276 | biological_process | gamete generation |
| C | 0000786 | cellular_component | nucleosome |
| C | 0003677 | molecular_function | DNA binding |
| C | 0030527 | molecular_function | structural constituent of chromatin |
| D | 0007276 | biological_process | gamete generation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MRD B 301 |
| Chain | Residue |
| A | ARG8 |
| B | TRP62 |
| B | TRP72 |
| B | TYR98 |
| B | HOH432 |
| B | HOH434 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MPD B 302 |
| Chain | Residue |
| B | ASP257 |
| B | GLU171 |
| B | VAL242 |
| B | VAL255 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 303 |
| Chain | Residue |
| B | HOH414 |
| B | HOH428 |
| B | HOH431 |
| D | HOH421 |
| D | HOH422 |
| D | HOH428 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 304 |
| Chain | Residue |
| B | ARG152 |
| B | LYS172 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MPD D 301 |
| Chain | Residue |
| D | TRP62 |
| D | TRP72 |
| D | TYR98 |
| D | LEU100 |
| D | PHE251 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MPD D 302 |
| Chain | Residue |
| D | MET154 |
| D | GLU171 |
| D | HOH502 |
| D | HOH526 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL D 303 |
| Chain | Residue |
| B | ARG152 |
| D | ARG152 |
| D | LYS172 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL D 304 |
| Chain | Residue |
| D | TRP165 |
Functional Information from PROSITE/UniProt
| site_id | PS00322 |
| Number of Residues | 7 |
| Details | HISTONE_H3_1 Histone H3 signature 1. KAPRKQL |
| Chain | Residue | Details |
| A | LYS14-LEU20 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"5-glutamyl serotonin; alternate","evidences":[{"source":"PubMed","id":"30867594","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 126 |
| Details | Region: {"description":"Tudor-like domain 1","evidences":[{"source":"PubMed","id":"23077255","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24589551","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | Region: {"description":"Histone H3K4me3 and H3R8me2a binding","evidences":[{"source":"PubMed","id":"23077255","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24589551","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 122 |
| Details | Region: {"description":"Tudor-like domain 2","evidences":[{"source":"PubMed","id":"23077255","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24589551","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | Site: {"description":"Histone H3K4me3 and H3R8me2a binding","evidences":[{"source":"PubMed","id":"23077255","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24589551","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by AURKA","evidences":[{"source":"PubMed","id":"22258766","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by AURKA","evidences":[{"source":"PubMed","id":"22258766","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
