4MYA
Crystal Structure of the Inosine 5'-monophosphate Dehydrogenase with an Internal Deletion of the CBS Domain from Bacillus anthracis str. Ames complexed with inhibitor A110
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Inosine-5'-monophosphate dehydrogenase | polymer | 384 | 40709.6 | 2 | UniProt (Q81W29) Pfam (PF00478) UniProt (by SIFTS) (A0A6L8P2U9) In PDB | Bacillus anthracis (anthrax anthrax bacterium) | IMP dehydrogenase, IMPD, IMPDH |
2 | A, B | INOSINIC ACID | non-polymer | 348.2 | 2 | Chemie (IMP) | |||
3 | A, B | 4-{(1R)-1-[1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl]ethoxy}quinolin-2(1H)-one | non-polymer | 366.8 | 2 | Chemie (2EY) | |||
4 | A, B | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
5 | water | water | 18.0 | 491 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 91 (UniProt: Q81W29)
A, B: 221 - 487 (UniProt: Q81W29)
PDB | External Database | Details |
---|---|---|
Met -23 | - | expression tag |
His -22 | - | expression tag |
His -21 | - | expression tag |
His -20 | - | expression tag |
His -19 | - | expression tag |
His -18 | - | expression tag |
His -17 | - | expression tag |
Ser -16 | - | expression tag |
Ser -15 | - | expression tag |
Gly -14 | - | expression tag |
Val -13 | - | expression tag |
Asp -12 | - | expression tag |
Leu -11 | - | expression tag |
Gly -10 | - | expression tag |
Thr -9 | - | expression tag |
Glu -8 | - | expression tag |
Asn -7 | - | expression tag |
Leu -6 | - | expression tag |
Tyr -5 | - | expression tag |
Phe -4 | - | expression tag |
Gln -3 | - | expression tag |
Ser -2 | - | expression tag |
Asn -1 | - | expression tag |
Ala 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 92 | - | linker |
Gly 220 | - | linker |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 81419.1 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 1706.3 | |
All* | Total formula weight | 83125.4 |