4MXP

Structural Basis for PI(4)P-Specific Membrane Recruitment of the Legionella pneumophila Effector DrrA/SidM

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Defects in Rab1 recruitment protein A	polymer	328	37114.2	1	UniProt (Q5ZSQ3) Pfam (PF20851) Pfam (PF14860)	Legionella pneumophila subsp. pneumophila	Multifunctional virulence effector protein DrrA, Adenosine monophosphate-protein transferase, AMPylator, Guanosine monophosphate-protein transferase, GMPylator, Rab1 guanine nucleotide exchange factor
2	B (A)	(2R)-3-{[(R)-hydroxy{[(1R,2R,3R,4R,5S,6R)-2,3,5,6-tetrahydroxy-4-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dibutanoate	non-polymer		554.4	1	Chemie (DB4)
3	C (A)	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
4	D (A)	water	water		18.0	195	Chemie (HOH)

Sequence modifications

A: 330 - 647 (UniProt: Q5ZSQ3)

PDB	External Database	Details
Met 320	-	expression tag
Gly 321	-	expression tag
His 322	-	expression tag
His 323	-	expression tag
His 324	-	expression tag
His 325	-	expression tag
His 326	-	expression tag
His 327	-	expression tag
Gly 328	-	expression tag
Ser 329	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	37114.2
Non-Polymers*	Number of molecules	2
	Total formula weight	577.4
All*	Total formula weight	37691.6

*Water molecules are not included.