4MU3
The form A structure of an E21Q catalytic mutant of A. thaliana IGPD2 in complex with Mn2+ and a mixture of its substrate, 2R3S-IGP, and an inhibitor, 2S3S-IGP, to 1.12 A resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Imidazoleglycerol-phosphate dehydratase 2, chloroplastic | polymer | 205 | 22390.1 | 1 | UniProt (O23346) Pfam (PF00475) | Arabidopsis thaliana (mouse-ear cress) | IGPD 2, Protein HISTIDINE BIOSYNTHESIS 5B |
| 2 | B, C (A) | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) | |||
| 3 | D (A) | (2S,3S)-2,3-dihydroxy-3-(1H-imidazol-5-yl)propyl dihydrogen phosphate | non-polymer | 238.1 | 1 | Chemie (IG2) | |||
| 4 | E (A) | (2R,3S)-2,3-dihydroxy-3-(1H-imidazol-5-yl)propyl dihydrogen phosphate | non-polymer | 238.1 | 1 | Chemie (IYP) | |||
| 5 | F, G, H, I, J (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 6 | K (A) | water | water | 18.0 | 205 | Chemie (HOH) |
Sequence modifications
A: 4 - 207 (UniProt: O23346)
| PDB | External Database | Details |
|---|---|---|
| Met 3 | - | initiating methionine |
| Gln 21 | Glu 86 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 22390.1 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 896.5 | |
| All* | Total formula weight | 23286.6 |
