4MU3

The form A structure of an E21Q catalytic mutant of A. thaliana IGPD2 in complex with Mn2+ and a mixture of its substrate, 2R3S-IGP, and an inhibitor, 2S3S-IGP, to 1.12 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000105	biological_process	L-histidine biosynthetic process
A	0004424	molecular_function	imidazoleglycerol-phosphate dehydratase activity

Functional Information from PROSITE/UniProt

site_id	PS00954
Number of Residues	14
Details	IGP_DEHYDRATASE_1 Imidazoleglycerol-phosphate dehydratase signature 1. IDdHHtnEdvALAI

Chain	Residue	Details
A	ILE70-ILE83

---

site_id	PS00955
Number of Residues	13
Details	IGP_DEHYDRATASE_2 Imidazoleglycerol-phosphate dehydratase signature 2. GkNsHHiiEAtFK

Chain	Residue	Details
A	GLY165-LYS177

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27717128","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5EKW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5EL9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ELW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26095028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27717128","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4MU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QNK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5EKW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ELW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26095028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27717128","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4MU0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MU1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QNJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QNK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5EKW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5EL9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ELW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26095028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27717128","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4MU1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5EKW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5EL9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ELW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26095028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27717128","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4MU0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QNJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QNK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ELW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26095028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27717128","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4MU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QNK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5EKW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5EL9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ELW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26095028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27717128","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4MU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5EKW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5EL9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ELW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26095028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27717128","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4MU1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QNK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5EKW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5EL9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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