4MQU

Human GKRP complexed to AMG-3969 and S6P

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Glucokinase regulatory protein	polymer	636	70178.5	2	UniProt (Q14397) Pfam (PF22645) Pfam (PF22198) Pfam (PF20741)	Homo sapiens (human)	Glucokinase regulator
2	C, Q (A, B)	2-{4-[(2S)-4-[(6-aminopyridin-3-yl)sulfonyl]-2-(prop-1-yn-1-yl)piperazin-1-yl]phenyl}-1,1,1,3,3,3-hexafluoropropan-2-ol	non-polymer		522.5	2	Chemie (MG9) PubChem (73053709) PubChem (76314158) PubChem (76321432)
3	D, R (A, B)	D-SORBITOL-6-PHOSPHATE	non-polymer		262.2	2	Chemie (S6P) PubChem (618) PubChem (130418) PubChem (152306) PubChem (440969) PubChem (445703) PubChem (14620017) PubChem (21968234) PubChem (17754155) PubChem (53827506) PubChem (92209470) PubChem (92177220) PubChem (124335010) PubChem (163321747) PubChem (165361689)
4	AA, BA, CA, DA, E... (B, A)	IODIDE ION	non-polymer		126.9	25	Chemie (IOD) PubChem (30165)
5	FA (B)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL) PubChem (753)
6	GA, HA, IA (B)	SULFATE ION	non-polymer		96.1	3	Chemie (SO4)
7	JA, KA (A, B)	water	water		18.0	233	Chemie (HOH)

Sequence modifications

A, B: 1 - 625 (UniProt: Q14397)

PDB	External Database	Details
Met -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
Asp -3	-	expression tag
Glu -2	-	expression tag
Val -1	-	expression tag
Asp 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	140357.0
Non-Polymers*	Number of molecules	33
	Total formula weight	5122.1
All*	Total formula weight	145479.1

*Water molecules are not included.