4MQU
Human GKRP complexed to AMG-3969 and S6P
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001678 | biological_process | intracellular glucose homeostasis |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0006606 | biological_process | protein import into nucleus |
| A | 0009749 | biological_process | response to glucose |
| A | 0009750 | biological_process | response to fructose |
| A | 0019210 | molecular_function | kinase inhibitor activity |
| A | 0033132 | biological_process | negative regulation of glucokinase activity |
| A | 0034504 | biological_process | protein localization to nucleus |
| A | 0046415 | biological_process | urate metabolic process |
| A | 0070095 | molecular_function | fructose-6-phosphate binding |
| A | 0070328 | biological_process | triglyceride homeostasis |
| A | 0097367 | molecular_function | carbohydrate derivative binding |
| A | 0141089 | molecular_function | glucose sensor activity |
| A | 1901135 | biological_process | carbohydrate derivative metabolic process |
| B | 0001678 | biological_process | intracellular glucose homeostasis |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005829 | cellular_component | cytosol |
| B | 0006606 | biological_process | protein import into nucleus |
| B | 0009749 | biological_process | response to glucose |
| B | 0009750 | biological_process | response to fructose |
| B | 0019210 | molecular_function | kinase inhibitor activity |
| B | 0033132 | biological_process | negative regulation of glucokinase activity |
| B | 0034504 | biological_process | protein localization to nucleus |
| B | 0046415 | biological_process | urate metabolic process |
| B | 0070095 | molecular_function | fructose-6-phosphate binding |
| B | 0070328 | biological_process | triglyceride homeostasis |
| B | 0097367 | molecular_function | carbohydrate derivative binding |
| B | 0141089 | molecular_function | glucose sensor activity |
| B | 1901135 | biological_process | carbohydrate derivative metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE MG9 A 701 |
| Chain | Residue |
| A | VAL28 |
| A | HIS504 |
| A | LYS514 |
| A | TRP517 |
| A | ALA521 |
| A | MET522 |
| A | ARG525 |
| A | IOD710 |
| A | HOH801 |
| A | HOH890 |
| A | PRO29 |
| A | GLU32 |
| A | SER34 |
| A | GLY181 |
| A | ASN209 |
| A | MET213 |
| A | ARG215 |
| A | ASP217 |
| site_id | AC2 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE S6P A 702 |
| Chain | Residue |
| A | GLY107 |
| A | GLY108 |
| A | THR109 |
| A | SER110 |
| A | GLU150 |
| A | GLU153 |
| A | SER179 |
| A | VAL180 |
| A | GLY181 |
| A | ALA184 |
| A | SER257 |
| A | SER258 |
| A | ARG259 |
| A | HIS351 |
| A | LYS514 |
| A | HOH835 |
| A | HOH836 |
| A | HOH852 |
| A | HOH859 |
| A | HOH874 |
| A | HOH884 |
| A | HOH885 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD A 703 |
| Chain | Residue |
| A | PHE472 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD A 705 |
| Chain | Residue |
| A | ARG73 |
| A | GLY250 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD A 706 |
| Chain | Residue |
| A | ALA46 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD A 707 |
| Chain | Residue |
| A | THR298 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD A 708 |
| Chain | Residue |
| A | GLY151 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD A 709 |
| Chain | Residue |
| A | GLY3 |
| A | LYS5 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IOD A 710 |
| Chain | Residue |
| A | GLU25 |
| A | LYS33 |
| A | MG9701 |
| site_id | BC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD A 711 |
| Chain | Residue |
| A | LYS531 |
| site_id | BC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD A 712 |
| Chain | Residue |
| A | ASN196 |
| site_id | BC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD A 713 |
| Chain | Residue |
| A | GLN529 |
| A | SER530 |
| site_id | BC4 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE MG9 B 701 |
| Chain | Residue |
| B | VAL28 |
| B | PRO29 |
| B | GLU32 |
| B | SER34 |
| B | GLY181 |
| B | MET213 |
| B | ARG215 |
| B | ASP217 |
| B | HIS504 |
| B | LYS514 |
| B | TRP517 |
| B | ALA521 |
| B | MET522 |
| B | ARG525 |
| B | IOD711 |
| B | HOH801 |
| B | HOH934 |
| site_id | BC5 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE S6P B 702 |
| Chain | Residue |
| B | GLY107 |
| B | THR109 |
| B | SER110 |
| B | GLU150 |
| B | GLU153 |
| B | SER179 |
| B | VAL180 |
| B | GLY181 |
| B | ALA184 |
| B | SER257 |
| B | SER258 |
| B | ARG259 |
| B | HIS351 |
| B | LYS514 |
| B | HOH853 |
| B | HOH855 |
| B | HOH886 |
| B | HOH892 |
| B | HOH901 |
| B | HOH913 |
| B | HOH916 |
| site_id | BC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD B 703 |
| Chain | Residue |
| B | PHE472 |
| site_id | BC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD B 705 |
| Chain | Residue |
| B | ARG73 |
| B | GLY250 |
| site_id | BC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD B 706 |
| Chain | Residue |
| B | THR298 |
| site_id | BC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD B 707 |
| Chain | Residue |
| B | ALA46 |
| site_id | CC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD B 708 |
| Chain | Residue |
| B | GLY151 |
| site_id | CC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD B 709 |
| Chain | Residue |
| B | SER530 |
| site_id | CC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IOD B 710 |
| Chain | Residue |
| B | GLY3 |
| B | LYS5 |
| B | ALA554 |
| site_id | CC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE IOD B 711 |
| Chain | Residue |
| B | GLU25 |
| B | LYS33 |
| B | SER34 |
| B | MG9701 |
| site_id | CC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD B 713 |
| Chain | Residue |
| B | LEU445 |
| B | SER458 |
| site_id | CC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD B 714 |
| Chain | Residue |
| B | ASN196 |
| site_id | CC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 716 |
| Chain | Residue |
| B | GLY354 |
| B | ASP507 |
| B | ARG509 |
| B | LYS567 |
| B | GLU568 |
| B | GLN569 |
| B | HOH808 |
| site_id | CC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 717 |
| Chain | Residue |
| B | ALA44 |
| B | ASP45 |
| site_id | CC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 718 |
| Chain | Residue |
| B | LYS18 |
| B | LEU21 |
| B | SER22 |
| B | HOH852 |
| site_id | DC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 719 |
| Chain | Residue |
| B | GLN336 |
| B | THR337 |
| B | LEU364 |
Functional Information from PROSITE/UniProt
| site_id | PS01272 |
| Number of Residues | 18 |
| Details | GCKR Glucokinase regulatory protein family signature. GPEgLSGSSRMKGGSatK |
| Chain | Residue | Details |
| A | GLY250-LYS267 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 392 |
| Details | Domain: {"description":"SIS 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00797","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Region: {"description":"Important for interaction with GCK","evidences":[{"source":"UniProtKB","id":"Q07071","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Region: {"description":"Essential for interaction with GCK","evidences":[{"source":"PubMed","id":"23733961","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q07071","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23621087","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BB9","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
