4MPV
Human beta-tryptase co-crystal structure with (2R,4S)-N,N'-bis[3-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)phenyl]-4-hydroxy-2-(2-hydroxypropan-2-yl)-5,5-dimethyl-1,3-dioxolane-2,4-dicarboxamide
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B (A, B) | Tryptase alpha/beta-1 | polymer | 245 | 27491.4 | 2 | UniProt (Q15661) Pfam (PF00089) | Homo sapiens (human) | Tryptase-1, Tryptase I, Tryptase alpha-1 |
2 | C (A) | (2R,4S)-N,N'-bis[3-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)phenyl]-4-hydroxy-2-(2-hydroxypropan-2-yl)-5,5-dimethyl-1,3-dioxolane-2,4-dicarboxamide | non-polymer | 847.0 | 1 | Chemie (2A4) | |||
3 | D, F, H, I (A, B) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
4 | E, G (A, B) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 2 | Chemie (MES) | |||
5 | J (B) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
6 | K, L (A, B) | water | water | 18.0 | 154 | Chemie (HOH) |
Sequence modifications
A, B: 31 - 275 (UniProt: Q15661)
PDB | External Database | Details |
---|---|---|
Lys 132 | Asn 132 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 54982.9 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 1657.2 | |
All* | Total formula weight | 56640.0 |