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4MPV

Human beta-tryptase co-crystal structure with (2R,4S)-N,N'-bis[3-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)phenyl]-4-hydroxy-2-(2-hydroxypropan-2-yl)-5,5-dimethyl-1,3-dioxolane-2,4-dicarboxamide

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
Tryptase alpha/beta-1polymer24527491.42UniProt (Q15661)
Pfam (PF00089)
Homo sapiens (human)Tryptase-1, Tryptase I, Tryptase alpha-1
2C
(A)
(2R,4S)-N,N'-bis[3-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)phenyl]-4-hydroxy-2-(2-hydroxypropan-2-yl)-5,5-dimethyl-1,3-dioxolane-2,4-dicarboxamidenon-polymer847.01Chemie (2A4)
3D, F, H, I
(A, B)
SULFATE IONnon-polymer96.14Chemie (SO4)
4E, G
(A, B)
2-(N-MORPHOLINO)-ETHANESULFONIC ACIDnon-polymer195.22Chemie (MES)
5J
(B)
CHLORIDE IONnon-polymer35.51Chemie (CL)
6K, L
(A, B)
waterwater18.0154Chemie (HOH)
Sequence modifications
A, B: 31 - 275 (UniProt: Q15661)
PDBExternal DatabaseDetails
Lys 132Asn 132SEE REMARK 999
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight54982.9
Non-Polymers*Number of molecules8
Total formula weight1657.2
All*Total formula weight56640.0
*Water molecules are not included.

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PDB entries from 2024-11-13

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