4MOY

Structure of a second nuclear PP1 Holoenzyme, crystal form 1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit	polymer	299	34162.1	1	UniProt (P62136) Pfam (PF16891) Pfam (PF00149) In PDB	Homo sapiens (human)	PP-1A
2	B	Serine/threonine-protein phosphatase 1 regulatory subunit 10	polymer	44	5218.9	1	UniProt (O55000) In PDB	Rattus norvegicus (brown rat rat rats)	MHC class I region proline-rich protein CAT53, Phosphatase 1 nuclear targeting subunit, Protein PNUTS
3	A	MANGANESE (II) ION	non-polymer		54.9	2	Chemie (MN)
4	A	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
5	A	PHOSPHATE ION	non-polymer		95.0	1	Chemie (PO4)
6	A	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
7		water	water		18.0	159	Chemie (HOH)

Sequence modifications

A: 7 - 300 (UniProt: P62136)

PDB	External Database	Details
Gly 2	-	expression tag
His 3	-	expression tag
Met 4	-	expression tag
Gly 5	-	expression tag
Ser 6	-	expression tag

B: 393 - 433 (UniProt: O55000)

PDB	External Database	Details
Gly 390	-	expression tag
Ala 391	-	expression tag
Met 392	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	39381.0
Non-Polymers*	Number of molecules	6
	Total formula weight	424.5
All*	Total formula weight	39805.5

*Water molecules are not included.