4MMY
Integrin AlphaVBeta3 ectodomain bound to the tenth domain of Fibronectin with the IAKGDWND motif
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Integrin alpha-V | polymer | 959 | 106048.4 | 1 | UniProt (P06756) Pfam (PF01839) Pfam (PF08441) Pfam (PF20805) Pfam (PF20806) In PDB | Homo sapiens (human) | Vitronectin receptor subunit alpha, Integrin alpha-V heavy chain, Integrin alpha-V light chain |
| 2 | B | Integrin beta-3 | polymer | 692 | 76523.1 | 1 | UniProt (P05106) Pfam (PF07974) Pfam (PF07965) Pfam (PF17205) Pfam (PF00362) Pfam (PF18372) In PDB | Homo sapiens (human) | Platelet membrane glycoprotein IIIa, GPIIIa |
| 3 | C | Fibronectin | polymer | 98 | 10505.8 | 1 | UniProt (P02751) Pfam (PF00041) In PDB | Homo sapiens (human) | FN, Cold-insoluble globulin, CIG |
| 4 | D, G | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 2 | In PDB GlyTouCan (G81315DD) | |||
| 5 | E, H, I, K | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
| 6 | F | alpha-D-mannopyranose-(1-4)-beta-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G93290PO) | |||
| 7 | J, L | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
| 8 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) | |||
| 9 | A, B | MANGANESE (II) ION | non-polymer | 54.9 | 8 | Chemie (MN) | |||
| 10 | water | water | 18.0 | 5 | Chemie (HOH) |
Sequence modifications
C: 1417 - 1509 (UniProt: P02751)
| PDB | External Database | Details |
|---|---|---|
| Ile 1491 | Thr 1522 | engineered mutation |
| Ala 1492 | Gly 1523 | engineered mutation |
| Trp 1496 | Ser 1527 | engineered mutation |
| Asn 1497 | Pro 1528 | engineered mutation |
| Asp 1498 | Ala 1529 | engineered mutation |
| Gly 1499 | Ser 1530 | engineered mutation |
| Gly 1510 | - | expression tag |
| Lys 1511 | - | expression tag |
| Lys 1512 | - | expression tag |
| Gly 1513 | - | expression tag |
| Lys 1514 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 193077.2 | |
| Branched | Number of molecules | 9 |
| Total formula weight | 5441.0 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 1545.5 | |
| All* | Total formula weight | 200063.8 |
