4MK4

S197C variant of human ferrochelatase.

Replaces:  4F4G

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Ferrochelatase, mitochondrial	polymer	359	41194.4	2	UniProt (P22830) Pfam (PF00762)	Homo sapiens (human)	Heme synthase, Protoheme ferro-lyase
2	C, G (A, B)	FE2/S2 (INORGANIC) CLUSTER	non-polymer		175.8	2	Chemie (FES)
3	D (A)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL) PubChem (753)
4	E, F, H, I, J (A, B)	CHOLIC ACID	non-polymer		408.6	5	Chemie (CHD) PubChem (16401672) PubChem (16758100) PubChem (18528842) PubChem (20638765) PubChem (23636694) PubChem (23640631) PubChem (23876184) PubChem (24836753) PubChem (24883735) PubChem (43835083) PubChem (44135469) PubChem (44629918) PubChem (44657327) PubChem (45114537) PubChem (45382168) PubChem (46397523) PubChem (46783697) PubChem (49791911) PubChem (49796810) PubChem (50989873) PubChem (51432410) PubChem (51546373) PubChem (16401251) PubChem (21139644) PubChem (53298695) PubChem (1762378) PubChem (44339334) PubChem (46780112) PubChem (53393606) PubChem (53477699) PubChem (59130005) PubChem (59381614) PubChem (59903914) PubChem (67122255) PubChem (69904012) PubChem (57937243) PubChem (130213) PubChem (145883) PubChem (70866085) PubChem (71001249) PubChem (239672) PubChem (71314856) PubChem (71752895) PubChem (58133002) PubChem (58582306) PubChem (74765127) PubChem (89830646) PubChem (91128541) PubChem (58984417) PubChem (59032051) PubChem (5283876) PubChem (5283879) PubChem (5283880) PubChem (5283872) PubChem (5283874) PubChem (98044963) PubChem (59316662) PubChem (99565617) PubChem (59877711) PubChem (59963674) PubChem (59997751) PubChem (60076012) PubChem (60098994) PubChem (60114995) PubChem (66678354) PubChem (122645815) PubChem (124161889) PubChem (124318072) PubChem (124488681) PubChem (125037036) PubChem (126577457) PubChem (129274856) PubChem (129274855) PubChem (129359810) PubChem (68097396) PubChem (68131418) PubChem (68318251) PubChem (68338620) PubChem (68372213) PubChem (71260265) PubChem (70649328) PubChem (133135020) PubChem (133126746) PubChem (11350342) PubChem (70824975) PubChem (70930320) PubChem (70930789) PubChem (70960845) PubChem (303) PubChem (12303168) PubChem (6676) PubChem (13020196) PubChem (122340) PubChem (91810856) PubChem (160636) PubChem (221493) PubChem (376829) PubChem (439520) PubChem (440427) PubChem (162771689) PubChem (99564899) PubChem (99565857) PubChem (163059393) PubChem (163059399) PubChem (163059389) PubChem (637625) PubChem (166858402) PubChem (117684834) PubChem (117767695) PubChem (117944573) PubChem (118241311) PubChem (121232934) PubChem (3246132) PubChem (122537896) PubChem (122537897) PubChem (122644681) PubChem (122644923) PubChem (122646384) PubChem (124328806) PubChem (124364505) PubChem (124425250) PubChem (124488680) PubChem (124511215) PubChem (124518077) PubChem (124518078) PubChem (124518446) PubChem (5283869) PubChem (5283870) PubChem (5283871) PubChem (5283873) PubChem (5283875) PubChem (5283877) PubChem (5283878) PubChem (124761950) PubChem (5302608) PubChem (5315844) PubChem (124841930) PubChem (124896923) PubChem (124896924) PubChem (124896925) PubChem (124896926) PubChem (124904187) PubChem (124904188) PubChem (124906682) PubChem (124906683) PubChem (124914603) PubChem (124914604) PubChem (124914605) PubChem (124914606) PubChem (125027431) PubChem (125037037) PubChem (126422551) PubChem (126422552) PubChem (126577461) PubChem (126672319) PubChem (126969154) PubChem (6708709) PubChem (6850901) PubChem (6850905) PubChem (129106816) PubChem (129460958) PubChem (129600748) PubChem (129628082) PubChem (130220803) PubChem (131700165) PubChem (132441695) PubChem (9802771) PubChem (133548348) PubChem (133612061) PubChem (133655733) PubChem (133687870) PubChem (9846429) PubChem (9866174) PubChem (133688934) PubChem (134462403) PubChem (134555902) PubChem (134866321) PubChem (135373095) PubChem (71172094) PubChem (137474142) PubChem (138107312) PubChem (12080557) PubChem (139248576) PubChem (139291795) PubChem (139372812) PubChem (12303167) PubChem (12303172) PubChem (12303175) PubChem (12303178) PubChem (12303180) PubChem (140618124) PubChem (141854542) PubChem (142134118) PubChem (143658950) PubChem (144316980) PubChem (145264188) PubChem (145714625) PubChem (146030145) PubChem (146665897) PubChem (154033190) PubChem (154036252) PubChem (13020205) PubChem (154747009) PubChem (154825357) PubChem (155275443) PubChem (155605940) PubChem (157048615) PubChem (157269375) PubChem (157351909) PubChem (157383333) PubChem (158041002) PubChem (158420924) PubChem (158675416) PubChem (160081178) PubChem (160743345) PubChem (160917187) PubChem (161973449) PubChem (163059390) PubChem (163059391) PubChem (163059392) PubChem (163059394) PubChem (163059395) PubChem (163059396) PubChem (163059397) PubChem (163059398) PubChem (163059400) PubChem (163452349) PubChem (163452350) PubChem (163452351) PubChem (167344826) PubChem (168841979) PubChem (168841990) PubChem (168845540) PubChem (169410142) PubChem (169436432) PubChem (171721516) PubChem (157060709)
5	K, L (A, B)	water	water		18.0	142	Chemie (HOH)

Sequence modifications

A, B: 65 - 423 (UniProt: P22830)

PDB	External Database	Details
Cys 197	Ser 197	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	82388.9
Non-Polymers*	Number of molecules	8
	Total formula weight	2486.6
All*	Total formula weight	84875.5

*Water molecules are not included.