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4MK4

S197C variant of human ferrochelatase.

Replaces:  4F4G
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
Ferrochelatase, mitochondrialpolymer35941194.42UniProt (P22830)
Pfam (PF00762)
Homo sapiens (human)Heme synthase, Protoheme ferro-lyase
2C, G
(A, B)
FE2/S2 (INORGANIC) CLUSTERnon-polymer175.82Chemie (FES)
3D
(A)
GLYCEROLnon-polymer92.11Chemie (GOL)
4E, F, H, I, J
(A, B)
CHOLIC ACIDnon-polymer408.65Chemie (CHD)
5K, L
(A, B)
waterwater18.0142Chemie (HOH)
Sequence modifications
A, B: 65 - 423 (UniProt: P22830)
PDBExternal DatabaseDetails
Cys 197Ser 197engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight82388.9
Non-Polymers*Number of molecules8
Total formula weight2486.6
All*Total formula weight84875.5
*Water molecules are not included.

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PDB entries from 2025-12-17

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