4MHA
Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC1817
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Tyrosine-protein kinase Mer | polymer | 313 | 35889.4 | 2 | UniProt (Q12866) Pfam (PF07714) In PDB | Homo sapiens (human) | Proto-oncogene c-Mer, Receptor tyrosine kinase MerTK |
2 | A, B | CHLORIDE ION | non-polymer | 35.5 | 6 | Chemie (CL) | |||
3 | A, B | 2-(butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-(4-sulfamoylbenzyl)pyrimidine-5-carboxamide | non-polymer | 476.6 | 2 | Chemie (4MH) | |||
4 | B | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
5 | water | water | 18.0 | 23 | Chemie (HOH) |
Sequence modifications
A, B: 570 - 864 (UniProt: Q12866)
PDB | External Database | Details |
---|---|---|
Met 552 | - | expression tag |
Gly 553 | - | expression tag |
Ser 554 | - | expression tag |
Ser 555 | - | expression tag |
His 556 | - | expression tag |
His 557 | - | expression tag |
His 558 | - | expression tag |
His 559 | - | expression tag |
His 560 | - | expression tag |
His 561 | - | expression tag |
Ser 562 | - | expression tag |
Ser 563 | - | expression tag |
Gly 564 | - | expression tag |
Leu 565 | - | expression tag |
Val 566 | - | expression tag |
Pro 567 | - | expression tag |
Arg 568 | - | expression tag |
Gly 569 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 71778.9 | |
Non-Polymers* | Number of molecules | 9 |
Total formula weight | 1190.2 | |
All* | Total formula weight | 72969.1 |