4MGY
Selective activation of Epac1 and Epac2
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | E | Rap guanine nucleotide exchange factor 4 | polymer | 694 | 79276.8 | 1 | UniProt (Q9EQZ6) Pfam (PF00027) Pfam (PF00618) Pfam (PF00617) In PDB | Mus musculus (mouse) | Exchange factor directly activated by cAMP 2, Exchange protein directly activated by cAMP 2, EPAC 2, cAMP-dependent Rap1 guanine-nucleotide exchange factor, cAMP-regulated guanine nucleotide exchange factor II, cAMP-GEFII |
2 | R | Ras-related protein Rap-1b | polymer | 167 | 19020.5 | 1 | UniProt (P61224) Pfam (PF00071) In PDB | Homo sapiens (human) | GTP-binding protein smg p21B |
3 | E | (2S,4aR,6R,7R,7aR)-6-{6-amino-8-[(4-chlorophenyl)sulfanyl]-9H-purin-9-yl}-7-methoxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-ol 2-oxide | non-polymer | 485.8 | 1 | Chemie (H07) | |||
4 | R | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
5 | water | water | 18.0 | 231 | Chemie (HOH) |
Sequence modifications
E: 306 - 993 (UniProt: Q9EQZ6)
PDB | External Database | Details |
---|---|---|
Gly 300 | - | expression tag |
Ser 301 | - | expression tag |
Pro 302 | - | expression tag |
Glu 303 | - | expression tag |
Ser 304 | - | expression tag |
Phe 305 | - | expression tag |
Gln 405 | Lys 423 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 98297.3 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 581.9 | |
All* | Total formula weight | 98879.2 |