4MGY
Selective activation of Epac1 and Epac2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (E) | Rap guanine nucleotide exchange factor 4 | polymer | 694 | 79276.8 | 1 | UniProt (Q9EQZ6) Pfam (PF00027) Pfam (PF00618) Pfam (PF00617) | Mus musculus (mouse) | Exchange factor directly activated by cAMP 2, Exchange protein directly activated by cAMP 2, EPAC 2, cAMP-dependent Rap1 guanine-nucleotide exchange factor, cAMP-regulated guanine nucleotide exchange factor II, cAMP-GEFII |
| 2 | B (R) | Ras-related protein Rap-1b | polymer | 167 | 19020.5 | 1 | UniProt (P61224) Pfam (PF00071) | Homo sapiens (human) | GTP-binding protein smg p21B |
| 3 | C (E) | (2S,4aR,6R,7R,7aR)-6-{6-amino-8-[(4-chlorophenyl)sulfanyl]-9H-purin-9-yl}-7-methoxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-ol 2-oxide | non-polymer | 485.8 | 1 | Chemie (H07) | |||
| 4 | D (R) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 5 | E, F (E, R) | water | water | 18.0 | 231 | Chemie (HOH) |
Sequence modifications
E: 306 - 993 (UniProt: Q9EQZ6)
| PDB | External Database | Details |
|---|---|---|
| Gly 300 | - | expression tag |
| Ser 301 | - | expression tag |
| Pro 302 | - | expression tag |
| Glu 303 | - | expression tag |
| Ser 304 | - | expression tag |
| Phe 305 | - | expression tag |
| Gln 405 | Lys 423 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 98297.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 581.9 | |
| All* | Total formula weight | 98879.2 |
