4MG6
Crystal structure of hERa-LBD (Y537S) in complex with benzylbutylphtalate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Estrogen receptor | polymer | 255 | 29070.2 | 2 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (human) | ER, ER-alpha, Estradiol receptor, Nuclear receptor subfamily 3 group A member 1 |
| 2 | C, D (C, D) | Nuclear receptor coactivator 1 | polymer | 13 | 1591.9 | 2 | UniProt (Q15788) | Homo sapiens | NCoA-1, Class E basic helix-loop-helix protein 74, bHLHe74, Protein Hin-2, RIP160, Renal carcinoma antigen NY-REN-52, Steroid receptor coactivator 1, SRC-1 |
| 3 | E, F (A, B) | benzyl butyl benzene-1,2-dicarboxylate | non-polymer | 312.4 | 2 | Chemie (27G) | |||
| 4 | G (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | H, I, J, K (A, B, C, D) | water | water | 18.0 | 309 | Chemie (HOH) |
Sequence modifications
A, B: 302 - 552 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Gly 298 | - | expression tag |
| Ser 299 | - | expression tag |
| His 300 | - | expression tag |
| Met 301 | - | expression tag |
| Ser 537 | Tyr 537 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 61324.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 716.8 | |
| All* | Total formula weight | 62041.0 |
