4MDR

Crystal structure of adaptor protein complex 4 (AP-4) mu4 subunit C-terminal domain D190A mutant, in complex with a sorting peptide from the amyloid precursor protein (APP)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	AP-4 complex subunit mu-1	polymer	301	33068.6	1	UniProt (O00189) Pfam (PF00928)	Homo sapiens (human)	AP-4 adapter complex mu subunit, Adapter-related protein complex 4 mu-1 subunit, Mu subunit of AP-4, Mu-adaptin-related protein 2, mu-ARP2, Mu4-adaptin, mu4
2	B (B)	Amyloid beta A4 protein	polymer	10	1303.4	1	UniProt (P05067)	Homo sapiens	ABPP, APPI, APP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, CVAP, PreA4, Protease nexin-II, PN-II, N-APP, Soluble APP-alpha, S-APP-alpha, Soluble APP-beta, S-APP-beta, C99, Beta-amyloid protein 42, Beta-APP42, Beta-amyloid protein 40, Beta-APP40, C83, P3(42), P3(40), C80, Gamma-secretase C-terminal fragment 59, Amyloid intracellular domain 59, AICD-59, AID(59), Gamma-CTF(59), Gamma-secretase C-terminal fragment 57, Amyloid intracellular domain 57, AICD-57, AID(57), Gamma-CTF(57), Gamma-secretase C-terminal fragment 50, Amyloid intracellular domain 50, AICD-50, AID(50), Gamma-CTF(50), C31
3	C, D (A, B)	water	water		18.0	97	Chemie (HOH)

Sequence modifications

A: 160 - 453 (UniProt: O00189)

PDB	External Database	Details
Gly 153	-	expression tag
Ala 154	-	expression tag
Met 155	-	expression tag
Asp 156	-	expression tag
Pro 157	-	expression tag
Glu 158	-	expression tag
Phe 159	-	expression tag
Ala 190	Asp 190	engineered mutation
Ser 235	Cys 235	engineered mutation
Ser 431	Cys 431	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	34372.0
All*	Total formula weight	34372.0

*Water molecules are not included.