4MDD
Crystal Structure of the Glucocorticoid Receptor Bound to a Non-steroidal Antagonist Reveals Repositioning and Partial Disordering of Activation Function Helix 12
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Glucocorticoid receptor | polymer | 258 | 29667.3 | 2 | UniProt (P04150) Pfam (PF00104) In PDB | Homo sapiens (human) | GR, Nuclear receptor subfamily 3 group C member 1 |
2 | C, D | Nuclear receptor corepressor 1 | polymer | 15 | 1631.9 | 2 | UniProt (O75376) In PDB | Homo sapiens | N-CoR, N-CoR1 |
3 | A, B | N-[2-{[benzyl(methyl)amino]methyl}-3-(4-fluoro-2-methoxyphenyl)-5-(propan-2-yl)-1H-indol-7-yl]methanesulfonamide | non-polymer | 509.6 | 2 | Chemie (29M) | |||
4 | water | water | 18.0 | 112 | Chemie (HOH) |
Sequence modifications
A, B: 522 - 777 (UniProt: P04150)
PDB | External Database | Details |
---|---|---|
Ser 520 | - | expression tag |
Ser 521 | - | expression tag |
Ser 525 | Leu 525 | engineered mutation |
Ser 528 | Leu 528 | engineered mutation |
Ala 535 | Leu 535 | engineered mutation |
Thr 538 | Val 538 | engineered mutation |
Tyr 602 | Phe 602 | engineered mutation |
Asp 638 | Cys 638 | engineered mutation |
Ala 684 | Glu 684 | engineered mutation |
Ala 688 | Glu 688 | engineered mutation |
Ser 712 | Trp 712 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 62598.5 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 1019.3 | |
All* | Total formula weight | 63617.8 |