4MDD
Crystal Structure of the Glucocorticoid Receptor Bound to a Non-steroidal Antagonist Reveals Repositioning and Partial Disordering of Activation Function Helix 12
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE 29M A 801 |
| Chain | Residue |
| A | MET560 |
| A | LEU563 |
| A | ASN564 |
| A | GLN570 |
| A | MET604 |
| A | ALA605 |
| A | LEU608 |
| A | CYS736 |
| A | THR739 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 29M B 801 |
| Chain | Residue |
| B | MET560 |
| B | LEU563 |
| B | ASN564 |
| B | GLY567 |
| B | GLN570 |
| B | MET604 |
| B | ALA605 |
| B | LEU608 |
| B | PHE623 |
| B | TYR735 |
| B | CYS736 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 330 |
| Details | Region: {"description":"Interaction with CRY1","evidences":[{"source":"PubMed","id":"22170608","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"PubMed","id":"12144530","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Motif: {"description":"CORNR box 3"} |
| Chain | Residue | Details |
