4M9F

Dengue virus NS2B-NS3 protease A125C variant at pH 8.5

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	NS2B-NS3 protease	polymer	247	26360.5	1	UniProt (Q91H74) Pfam (PF01002) Pfam (PF00949) UniProt (by SIFTS) (P12823)	Dengue virus 2
2	B (A)	water	water		18.0	36	Chemie (HOH)

Sequence modifications

A: 49 - 95 (UniProt: Q91H74)

PDB	External Database	Details
Gly 43	-	expression tag
Ser 44	-	expression tag
His 45	-	expression tag
Met 46	-	expression tag
Leu 47	-	expression tag
Glu 48	-	expression tag

A: 1001 - 1177 (UniProt: Q91H74)

PDB	External Database	Details
Gly 96	-	linker
Gly 993	-	linker
Gly 994	-	linker
Gly 995	-	linker
Ser 996	-	linker
Gly 997	-	linker
Gly 998	-	linker
Gly 999	-	linker
Gly 1000	-	linker
Cys 1125	Ala 1600	engineered mutation
Asn 1167	Gln 1642	conflict

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	26360.5
All*	Total formula weight	26360.5

*Water molecules are not included.