4M76

Integrin I domain of complement receptor 3 in complex with C3d

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Complement C3	polymer	298	33199.0	1	UniProt (P01024) Pfam (PF07678)	Homo sapiens (human)	C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1, Complement C3 beta chain, Complement C3 alpha chain, C3a anaphylatoxin, Acylation stimulating protein, ASP, C3adesArg, Complement C3b alpha' chain, Complement C3c alpha' chain fragment 1, Complement C3dg fragment, Complement C3g fragment, Complement C3d fragment, Complement C3f fragment, Complement C3c alpha' chain fragment 2
2	B (B)	Integrin alpha-M	polymer	198	22480.6	1	UniProt (P11215) Pfam (PF00092)	Homo sapiens (human)	CD11 antigen-like family member B, CR-3 alpha chain, Cell surface glycoprotein MAC-1 subunit alpha, Leukocyte adhesion receptor MO1, Neutrophil adherence receptor
3	C, D (A, B)	NICKEL (II) ION	non-polymer		58.7	2	Chemie (NI)
4	E, F (A, B)	water	water		18.0	33	Chemie (HOH)

Sequence modifications

A: 994 - 1288 (UniProt: P01024)

PDB	External Database	Details
Gly 991	-	expression tag
Ala 992	-	expression tag
Met 993	-	expression tag
Ala 1010	Cys 1010	engineered mutation

B: 127 - 321 (UniProt: P11215)

PDB	External Database	Details
Gly 124	-	expression tag
Ala 125	-	expression tag
Met 126	-	expression tag
Ser 128	Cys 144	engineered mutation
Gly 316	Ile 332	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	55679.6
Non-Polymers*	Number of molecules	2
	Total formula weight	117.4
All*	Total formula weight	55797.0

*Water molecules are not included.