4LZ8
Crystal structures of GLuR2 ligand-binding-domain in complex with glutamate and positive allosteric modulators
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Glutamate receptor 2 | polymer | 275 | 30343.8 | 3 | UniProt (P19491) Pfam (PF10613) Pfam (PF00060) | Rattus norvegicus (brown rat) | GluR-2, AMPA-selective glutamate receptor 2, GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA 2, GluA2, AMPA receptor |
| 2 | D, I, M (A, B, C) | GLUTAMIC ACID | non-polymer | 147.1 | 3 | Chemie (GLU) | |||
| 3 | E, J (A, B) | N-[(3S)-1-{2-fluoro-4-[(5S)-5-{[(propan-2-ylsulfonyl)amino]methyl}-4,5-dihydro-1,2-oxazol-3-yl]phenyl}pyrrolidin-3-yl]acetamide | non-polymer | 426.5 | 2 | Chemie (1YX) | |||
| 4 | F, G, H, K, L (B, C) | ZINC ION | non-polymer | 65.4 | 5 | Chemie (ZN) | |||
| 5 | N, O, P (A, B, C) | water | water | 18.0 | 346 | Chemie (HOH) |
Sequence modifications
A, B, C: 383 - 506 (UniProt: P19491)
A, B, C: 632 - 775 (UniProt: P19491)
| PDB | External Database | Details |
|---|---|---|
| Gly 378 | - | expression tag |
| Ser 379 | - | expression tag |
| Ala 380 | - | expression tag |
| Met 381 | - | expression tag |
| Gly 382 | - | expression tag |
| Arg 389 | Gly 410 | engineered mutation |
| Gly 390 | Leu 411 | engineered mutation |
| Ala 391 | Glu 412 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 507 | - | linker |
| Thr 508 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 91031.5 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1621.4 | |
| All* | Total formula weight | 92653.0 |
