4LZ8

Crystal structures of GLuR2 ligand-binding-domain in complex with glutamate and positive allosteric modulators

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GLU A 801

Chain	Residue
A	TYR450
A	TYR732
A	HOH1010
A	HOH1019
A	HOH1023
A	PRO478
A	LEU479
A	THR480
A	ARG485
A	GLY653
A	SER654
A	THR655
A	GLU705

---

site_id	AC2
Number of Residues	21
Details	BINDING SITE FOR RESIDUE 1YX A 802

Chain	Residue
A	LYS493
A	PRO494
A	PHE495
A	MET496
A	SER497
A	SER729
A	LYS730
A	VAL750
A	LEU751
A	ASN754
A	HOH1094
A	HOH1099
C	LYS493
C	PRO494
C	PHE495
C	MET496
C	SER497
C	SER729
C	LYS730
C	LEU751
C	ASN754

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN B 801

Chain	Residue
A	GLU431
A	HIS435
B	GLU678

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 802

Chain	Residue
B	HIS412
B	GLU419
B	HOH1003
C	HIS412

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN B 803

Chain	Residue
A	GLU678
B	GLU431
B	HIS435
B	LEU753
B	GLN756

---

site_id	AC6
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GLU B 804

Chain	Residue
B	TYR450
B	PRO478
B	LEU479
B	THR480
B	ARG485
B	GLY653
B	SER654
B	THR655
B	GLU705
B	TYR732
B	HOH903
B	HOH905
B	HOH909

---

site_id	AC7
Number of Residues	19
Details	BINDING SITE FOR RESIDUE 1YX B 805

Chain	Residue
B	LYS493
B	PRO494
B	PRO494
B	PHE495
B	MET496
B	MET496
B	SER497
B	SER497
B	SER729
B	SER729
B	LYS730
B	LYS730
B	VAL750
B	LEU751
B	LEU751
B	ASN754
B	HOH972
B	HOH986
B	HOH986

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN C 801

Chain	Residue
A	HIS412
C	ASP454
C	ASP456
C	HOH949
C	HOH986

---

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN C 802

Chain	Residue
C	GLU431
C	HIS435

---

site_id	BC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GLU C 803

Chain	Residue
C	TYR450
C	PRO478
C	LEU479
C	THR480
C	ARG485
C	LEU650
C	GLY653
C	SER654
C	THR655
C	GLU705
C	HOH902
C	HOH905
C	HOH906

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO

Chain	Residue	Details
A	PRO478
B	SER654
B	THR655
B	GLU705
C	PRO478
C	THR480
C	ARG485
C	SER654
C	THR655
C	GLU705
A	THR480
A	ARG485
A	SER654
A	THR655
A	GLU705
B	PRO478
B	THR480
B	ARG485

---

site_id	SWS_FT_FI2
Number of Residues	9
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ARG453
A	ARG660
A	LYS752
B	ARG453
B	ARG660
B	LYS752
C	ARG453
C	ARG660
C	LYS752

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ILE633
B	ILE633
C	ILE633

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER662
B	SER662
C	SER662

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER696
B	SER696
C	SER696

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN385
A	ASN392
B	ASN385
B	ASN392
C	ASN385
C	ASN392

---