4LXL
Crystal structure of JMJD2B complexed with pyridine-2,4-dicarboxylic acid and H3K9me3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Lysine-specific demethylase 4B | polymer | 368 | 42419.1 | 1 | UniProt (O94953) Pfam (PF02375) Pfam (PF02373) | Homo sapiens (human) | JmjC domain-containing histone demethylation protein 3B, Jumonji domain-containing protein 2B |
| 2 | B (D) | H3 peptide | polymer | 8 | 849.0 | 1 | UniProt (by SIFTS) (P68431) | human | |
| 3 | C (A) | PYRIDINE-2,4-DICARBOXYLIC ACID | non-polymer | 167.1 | 1 | Chemie (PD2) | |||
| 4 | D (A) | NICKEL (II) ION | non-polymer | 58.7 | 1 | Chemie (NI) | |||
| 5 | E (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 6 | F, G (A, D) | water | water | 18.0 | 262 | Chemie (HOH) |
Sequence modifications
A: 1 - 348 (UniProt: O94953)
| PDB | External Database | Details |
|---|---|---|
| Met -19 | - | expression tag |
| Gly -18 | - | expression tag |
| Ser -17 | - | expression tag |
| Ser -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| Ser -9 | - | expression tag |
| Ser -8 | - | expression tag |
| Gly -7 | - | expression tag |
| Leu -6 | - | expression tag |
| Val -5 | - | expression tag |
| Pro -4 | - | expression tag |
| Arg -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 43268.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 291.2 | |
| All* | Total formula weight | 43559.3 |
