4LXL
Crystal structure of JMJD2B complexed with pyridine-2,4-dicarboxylic acid and H3K9me3
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE PD2 A 401 |
| Chain | Residue |
| A | TYR133 |
| A | NI402 |
| A | HOH510 |
| A | HOH511 |
| A | HOH514 |
| A | HOH752 |
| D | M3L9 |
| D | HOH101 |
| A | TYR178 |
| A | PHE186 |
| A | HIS189 |
| A | GLU191 |
| A | LYS207 |
| A | TRP209 |
| A | LYS242 |
| A | HIS277 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NI A 402 |
| Chain | Residue |
| A | HIS189 |
| A | GLU191 |
| A | HIS277 |
| A | PD2401 |
| A | HOH752 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 403 |
| Chain | Residue |
| A | CYS235 |
| A | HIS241 |
| A | CYS307 |
| A | CYS309 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: Symmetric dimethylarginine; by PRMT5; alternate => ECO:0000250|UniProtKB:P68433 |
| Chain | Residue | Details |
| D | ARG8 | |
| A | ASN199 | |
| A | LYS207 | |
| A | LYS242 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:11242053, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708 |
| Chain | Residue | Details |
| D | M3L9 | |
| A | GLU191 | |
| A | HIS277 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; alternate; by AURKB, AURKC, RPS6KA3, RPS6KA4 and RPS6KA5 => ECO:0000269|PubMed:10464286, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:12560483, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16457588 |
| Chain | Residue | Details |
| D | SER10 | |
| A | HIS241 | |
| A | CYS307 | |
| A | CYS309 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by PKC and CHEK1 => ECO:0000269|PubMed:12560483, ECO:0000269|PubMed:18066052, ECO:0000269|PubMed:18243098, ECO:0000269|PubMed:22901803 |
| Chain | Residue | Details |
| D | THR11 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435 |
| Chain | Residue | Details |
| D | LYS14 |
