4LXK
Crystal Structure of Human Beta Secretase in Complex with compound 11d
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C | Beta-secretase 1 | polymer | 402 | 44777.3 | 3 | UniProt (P56817) Pfam (PF00026) In PDB | Homo sapiens (human) | Aspartyl protease 2, ASP2, Asp 2, Beta-site amyloid precursor protein cleaving enzyme 1, Beta-site APP cleaving enzyme 1, Memapsin-2, Membrane-associated aspartic protease 2 |
2 | A, B, C | (1R,3S,4S,5R)-3-(4-amino-3-fluoro-5-{[(2R)-1,1,1-trifluoro-3-methoxypropan-2-yl]oxy}benzyl)-5-[(3-tert-butylbenzyl)amino]tetrahydro-2H-thiopyran-4-ol 1-oxide | non-polymer | 560.6 | 3 | Chemie (1YT) | |||
3 | B | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
4 | water | water | 18.0 | 609 | Chemie (HOH) |
Sequence modifications
A, B, C: 35 - 386 (UniProt: P56817)
PDB | External Database | Details |
---|---|---|
Gly 33 | - | EXPRESSION TAG |
Pro 34 | - | EXPRESSION TAG |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 134332.0 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1774.0 | |
All* | Total formula weight | 136106.0 |