4LXD
Bcl_2-Navitoclax Analog (without Thiophenyl) Complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Apoptosis regulator Bcl-2 | polymer | 166 | 19383.6 | 1 | UniProt (P10415) Pfam (PF02180) Pfam (PF00452) | Homo sapiens (human) | |
| 2 | B (A) | 4-(4-{[4-(4-chlorophenyl)-5,6-dihydro-2H-pyran-3-yl]methyl}piperazin-1-yl)-N-{[3-nitro-4-(tetrahydro-2H-pyran-4-ylamino)phenyl]sulfonyl}benzamide | non-polymer | 696.2 | 1 | Chemie (1XV) | |||
| 3 | C (A) | water | water | 18.0 | 231 | Chemie (HOH) |
Sequence modifications
A: -1 - 32 (UniProt: P10415)
A: 89 - 204 (UniProt: P10415)
| PDB | External Database | Details |
|---|---|---|
| Pro 2 | Ala 4 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Asp 73 | - | linker |
| Val 74 | - | linker |
| Glu 75 | - | linker |
| Glu 76 | - | linker |
| Asn 77 | - | linker |
| Arg 78 | - | linker |
| Thr 79 | - | linker |
| Glu 80 | - | linker |
| Ala 81 | - | linker |
| Pro 82 | - | linker |
| Glu 83 | - | linker |
| Gly 84 | - | linker |
| Thr 85 | - | linker |
| Glu 86 | - | linker |
| Ser 87 | - | linker |
| Glu 88 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 19383.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 696.2 | |
| All* | Total formula weight | 20079.8 |
