4LXD

Bcl_2-Navitoclax Analog (without Thiophenyl) Complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0042981	biological_process	regulation of apoptotic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	23
Details	BINDING SITE FOR RESIDUE 1XV A 301

Chain	Residue
A	GLY25
A	MET112
A	VAL130
A	GLU133
A	LEU134
A	ASN140
A	TRP141
A	GLY142
A	ARG143
A	VAL145
A	ALA146
A	TYR26
A	TYR199
A	HOH419
A	HOH437
A	HOH578
A	GLU27
A	TRP28
A	ASP29
A	ALA30
A	ALA97
A	ASP100
A	TYR105

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Functional Information from PROSITE/UniProt

site_id	PS01080
Number of Residues	19
Details	BH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. LFrDGv.NWGRIVAFFeFGG

Chain	Residue	Details
A	LEU134-GLY152

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site_id	PS01258
Number of Residues	12
Details	BH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WIqdnGGWDaFV

Chain	Residue	Details
A	TRP185-VAL196

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site_id	PS01259
Number of Residues	15
Details	BH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. VhltLRqAGDDFSRR

Chain	Residue	Details
A	VAL90-ARG104

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site_id	PS01260
Number of Residues	21
Details	BH4_1 Apoptosis regulator, Bcl-2 family BH4 motif signature. DNREIVmKYIHYKLSQRGYeW

Chain	Residue	Details
A	ASP8-TRP28

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Motif: {"description":"BH4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00025","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	14
Details	Motif: {"description":"BH3","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	19
Details	Motif: {"description":"BH1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	15
Details	Motif: {"description":"BH2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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