4LWV
The 2.3A Crystal Structure of Humanized Xenopus MDM2 with RO5545353
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | E3 ubiquitin-protein ligase Mdm2 | polymer | 85 | 9831.4 | 3 | UniProt (P56273) Pfam (PF02201) | Xenopus laevis (clawed frog common platanna platanna) | Double minute 2 protein, Xdm2, p53-binding protein Mdm2 |
| 2 | D, H, I (A, B, C) | (2S,3R,4R,5R)-N-(4-carbamoyl-2-methoxyphenyl)-2'-chloro-4-(3-chloro-2-fluorophenyl)-2-(2,2-dimethylpropyl)-5'-oxo-4',5'-dihydrospiro[pyrrolidine-3,6'-thieno[3,2-b]pyrrole]-5-carboxamide | non-polymer | 619.5 | 3 | Chemie (20W) | |||
| 3 | E, F, G (A) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 4 | J, K, L (A, B, C) | water | water | 18.0 | 48 | Chemie (HOH) |
Sequence modifications
A, B, C: 21 - 105 (UniProt: P56273)
| PDB | External Database | Details |
|---|---|---|
| Leu 50 | Ile 50 | engineered mutation |
| His 92 | Pro 92 | engineered mutation |
| Ile 95 | Leu 95 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 29494.3 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 2146.8 | |
| All* | Total formula weight | 31641.0 |
