4LWV

The 2.3A Crystal Structure of Humanized Xenopus MDM2 with RO5545353

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0043066	biological_process	negative regulation of apoptotic process
A	0051726	biological_process	regulation of cell cycle
B	0005634	cellular_component	nucleus
B	0043066	biological_process	negative regulation of apoptotic process
B	0051726	biological_process	regulation of cell cycle
C	0005634	cellular_component	nucleus
C	0043066	biological_process	negative regulation of apoptotic process
C	0051726	biological_process	regulation of cell cycle

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 20W A 201

Chain	Residue
A	LEU50
C	LYS90
C	20W201
C	HOH308
A	HIS69
A	PHE82
A	VAL89
A	LYS90
A	HIS92
A	ILE95
A	TYR96
A	HOH314

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site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 202

Chain	Residue
A	HIS92
A	TYR96
A	HOH306
A	HOH317
C	LYS90
C	GLU91
C	HIS92
C	ARG93

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site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 203

Chain	Residue
A	LYS90
A	GLU91
A	HIS92
A	ARG93
A	HOH307
A	HOH315
C	HIS92
C	TYR96

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site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 204

Chain	Residue
A	PRO28
A	LEU29
B	PRO28
B	LEU29
C	PRO28
C	LEU29

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site_id	AC5
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 20W B 201

Chain	Residue
B	LEU50
B	MET58
B	TYR63
B	TYR63
B	GLU65
B	GLN68
B	GLN68
B	VAL89
B	LYS90
B	HIS92
B	ILE95
B	TYR96

---

site_id	AC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE 20W C 201

Chain	Residue
A	20W201
A	HOH314
C	LEU50
C	MET58
C	HIS69
C	VAL89
C	LYS90
C	HIS92
C	TYR96
C	HOH311

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