4LVT
Bcl_2-Navitoclax (ABT-263) Complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Apoptosis regulator Bcl-2 | polymer | 166 | 19383.6 | 2 | UniProt (P10415) Pfam (PF02180) Pfam (PF00452) In PDB | Homo sapiens (human) | |
| 2 | A, B | 4-(4-{[2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(2R)-4-(morpholin-4-yl)-1-(phenylsulfanyl)butan-2-yl]amino}-3-[(trifluoromethyl)sulfonyl]phenyl)sulfonyl]benzamide | non-polymer | 974.6 | 2 | Chemie (1XJ) | |||
| 3 | water | water | 18.0 | 175 | Chemie (HOH) |
Sequence modifications
A, B: -1 - 32 (UniProt: P10415)
A, B: 89 - 204 (UniProt: P10415)
| PDB | External Database | Details |
|---|---|---|
| Pro 2 | Ala 4 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Asp 73 | - | linker |
| Val 74 | - | linker |
| Glu 75 | - | linker |
| Glu 76 | - | linker |
| Asn 77 | - | linker |
| Arg 78 | - | linker |
| Thr 79 | - | linker |
| Glu 80 | - | linker |
| Ala 81 | - | linker |
| Pro 82 | - | linker |
| Glu 83 | - | linker |
| Gly 84 | - | linker |
| Thr 85 | - | linker |
| Glu 86 | - | linker |
| Ser 87 | - | linker |
| Glu 88 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 38767.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1949.2 | |
| All* | Total formula weight | 40716.4 |
