4LS0
Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH01B0033
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Dihydroorotate dehydrogenase (quinone), mitochondrial | polymer | 390 | 42636.4 | 1 | UniProt (Q02127) Pfam (PF01180) | Homo sapiens (human) | DHOdehase, Dihydroorotate oxidase |
| 2 | B (A) | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 1 | Chemie (FMN) | |||
| 3 | C (A) | OROTIC ACID | non-polymer | 156.1 | 1 | Chemie (ORO) | |||
| 4 | D, E, F, G, H... (A) | SULFATE ION | non-polymer | 96.1 | 10 | Chemie (SO4) | |||
| 5 | N (A) | 2-{(E)-[2-(4-phenyl-1,3-thiazol-2-yl)hydrazinylidene]methyl}benzaldehyde | non-polymer | 307.4 | 1 | Chemie (B3B) | |||
| 6 | O (A) | water | water | 18.0 | 199 | Chemie (HOH) |
Sequence modifications
A: 30 - 396 (UniProt: Q02127)
| PDB | External Database | Details |
|---|---|---|
| Met 7 | - | expression tag |
| Gly 8 | - | expression tag |
| His 9 | - | expression tag |
| His 10 | - | expression tag |
| His 11 | - | expression tag |
| His 12 | - | expression tag |
| His 13 | - | expression tag |
| His 14 | - | expression tag |
| His 15 | - | expression tag |
| His 16 | - | expression tag |
| His 17 | - | expression tag |
| His 18 | - | expression tag |
| Ser 19 | - | expression tag |
| Ser 20 | - | expression tag |
| Gly 21 | - | expression tag |
| His 22 | - | expression tag |
| Ile 23 | - | expression tag |
| Asp 24 | - | expression tag |
| Asp 25 | - | expression tag |
| Asp 26 | - | expression tag |
| Asp 27 | - | expression tag |
| Lys 28 | - | expression tag |
| His 29 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 42636.4 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 1880.4 | |
| All* | Total formula weight | 44516.9 |
