4LLQ
Structure of redesigned IgG1 first constant and lambda domains (CH1:Clambda constant redesign 2 beta, CRD2b) at 1.42A
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | mutated CH1 | polymer | 113 | 11671.1 | 1 | UniProt (Q6MZQ6) Pfam (PF07654) UniProt (by SIFTS) (P01857) In PDB | Homo sapiens (human) | |
2 | B | mutated light chain Clambda | polymer | 151 | 16025.0 | 1 | UniProt (Q6PJR7) Pfam (PF07654) UniProt (by SIFTS) (P0DOY2) In PDB | Homo sapiens (human) | |
3 | A | 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE | non-polymer | 266.3 | 1 | Chemie (PG6) | |||
4 | water | water | 18.0 | 203 | Chemie (HOH) |
Sequence modifications
A: 132 - 235 (UniProt: Q6MZQ6)
B: 110 - 215 (UniProt: Q6PJR7)
PDB | External Database | Details |
---|---|---|
Met 131 | - | expression tag |
Gly 185 | Phe 198 | engineered mutation |
Gly 236 | - | expression tag |
Ser 237 | - | expression tag |
His 238 | - | expression tag |
His 239 | - | expression tag |
His 240 | - | expression tag |
His 241 | - | expression tag |
His 242 | - | expression tag |
His 243 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met 89 | - | expression tag |
Lys 90 | - | expression tag |
Tyr 91 | - | expression tag |
Leu 92 | - | expression tag |
Leu 93 | - | expression tag |
Pro 94 | - | expression tag |
Thr 95 | - | expression tag |
Ala 96 | - | expression tag |
Ala 97 | - | expression tag |
Ala 98 | - | expression tag |
Gly 99 | - | expression tag |
Leu 100 | - | expression tag |
Leu 101 | - | expression tag |
Leu 102 | - | expression tag |
Leu 103 | - | expression tag |
Ala 104 | - | expression tag |
Ala 105 | - | expression tag |
Gln 106 | - | expression tag |
Pro 107 | - | expression tag |
Ala 108 | - | expression tag |
Met 109 | - | expression tag |
Ala 139 | Leu 61 | engineered mutation |
Trp 179 | Ser 101 | engineered mutation |
Leu 216 | - | expression tag |
Glu 217 | - | expression tag |
Ser 218 | - | expression tag |
Gly 219 | - | expression tag |
Lys 220 | - | expression tag |
Glu 221 | - | expression tag |
Thr 222 | - | expression tag |
Ala 223 | - | expression tag |
Ala 224 | - | expression tag |
Ala 225 | - | expression tag |
Lys 226 | - | expression tag |
Phe 227 | - | expression tag |
Glu 228 | - | expression tag |
Arg 229 | - | expression tag |
Gln 230 | - | expression tag |
His 231 | - | expression tag |
Met 232 | - | expression tag |
Asp 233 | - | expression tag |
Ser 234 | - | expression tag |
Ser 235 | - | expression tag |
Thr 236 | - | expression tag |
Ser 237 | - | expression tag |
Ala 238 | - | expression tag |
Ala 239 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 27696.1 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 266.3 | |
All* | Total formula weight | 27962.4 |