4LLM
Structure of redesigned IgG1 first constant and lambda domains (CH1:Clambda constant redesign 1, CRD1) at 1.75A
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Ig gamma-1 chain C region | polymer | 111 | 11575.0 | 1 | UniProt (P01857) Pfam (PF07654) In PDB | Homo sapiens (human) | |
2 | B | Ig lambda-2 chain C region | polymer | 129 | 13776.1 | 1 | UniProt (P0CG05) Pfam (PF07654) UniProt (by SIFTS) (P0DOY2) In PDB | Homo sapiens (human) | |
3 | water | water | 18.0 | 139 | Chemie (HOH) |
Sequence modifications
A: 133 - 235 (UniProt: P01857)
B: 111 - 215 (UniProt: P0CG05)
PDB | External Database | Details |
---|---|---|
Lys 163 | Asp 31 | engineered mutation |
Thr 185 | Phe 53 | engineered mutation |
Phe 200 | Val 68 | engineered mutation |
Gly 236 | - | expression tag |
Ser 237 | - | expression tag |
His 238 | - | expression tag |
His 239 | - | expression tag |
His 240 | - | expression tag |
His 241 | - | expression tag |
His 242 | - | expression tag |
His 243 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Asp 133 | Lys 23 | engineered mutation |
Phe 139 | Leu 29 | engineered mutation |
Leu 216 | - | expression tag |
Glu 217 | - | expression tag |
Ser 218 | - | expression tag |
Gly 219 | - | expression tag |
Lys 220 | - | expression tag |
Glu 221 | - | expression tag |
Thr 222 | - | expression tag |
Ala 223 | - | expression tag |
Ala 224 | - | expression tag |
Ala 225 | - | expression tag |
Lys 226 | - | expression tag |
Phe 227 | - | expression tag |
Glu 228 | - | expression tag |
Arg 229 | - | expression tag |
Gln 230 | - | expression tag |
His 231 | - | expression tag |
Met 232 | - | expression tag |
Asp 233 | - | expression tag |
Ser 234 | - | expression tag |
Ser 235 | - | expression tag |
Thr 236 | - | expression tag |
Ser 237 | - | expression tag |
Ala 238 | - | expression tag |
Ala 239 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 25351.1 | |
All* | Total formula weight | 25351.1 |