4LLD

Structure of wild-type IgG1 antibody heavy chain constant domain 1 and light chain lambda constant domain (IgG1 CH1:Clambda) at 1.19A

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Ig gamma-1 chain C region	polymer	111	11558.9	1	UniProt (P01857) Pfam (PF07654)	Homo sapiens (human)
2	B (B)	Ig lambda-2 chain C region	polymer	129	13756.2	1	UniProt (P0CG05) Pfam (PF07654) UniProt (by SIFTS) (P0DOY2)	Homo sapiens (human)
3	C, D (A, B)	water	water		18.0	330	Chemie (HOH)

Sequence modifications

A: 133 - 235 (UniProt: P01857)

PDB	External Database	Details
Gly 236	-	expression tag
Ser 237	-	expression tag
His 238	-	expression tag
His 239	-	expression tag
His 240	-	expression tag
His 241	-	expression tag
His 242	-	expression tag
His 243	-	expression tag

B: 111 - 215 (UniProt: P0CG05)

PDB	External Database	Details
Leu 216	-	expression tag
Glu 217	-	expression tag
Ser 218	-	expression tag
Gly 219	-	expression tag
Lys 220	-	expression tag
Glu 221	-	expression tag
Thr 222	-	expression tag
Ala 223	-	expression tag
Ala 224	-	expression tag
Ala 225	-	expression tag
Lys 226	-	expression tag
Phe 227	-	expression tag
Glu 228	-	expression tag
Arg 229	-	expression tag
Gln 230	-	expression tag
His 231	-	expression tag
Met 232	-	expression tag
Asp 233	-	expression tag
Ser 234	-	expression tag
Ser 235	-	expression tag
Thr 236	-	expression tag
Ser 237	-	expression tag
Ala 238	-	expression tag
Ala 239	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	25315.1
All*	Total formula weight	25315.1

*Water molecules are not included.