4LL4
The structure of the TRX and TXNIP complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Thioredoxin-interacting protein | polymer | 315 | 35037.5 | 2 | UniProt (Q9H3M7) Pfam (PF00339) Pfam (PF02752) | Homo sapiens (human) | Thioredoxin-binding protein 2, Vitamin D3 up-regulated protein 1 |
| 2 | B, D (B, D) | Thioredoxin | polymer | 105 | 11718.4 | 2 | UniProt (P10599) Pfam (PF00085) | Homo sapiens (human) | Trx, ATL-derived factor, ADF, Surface-associated sulphydryl protein, SASP |
| 3 | E, F, G, H (A, B, C, D) | water | water | 18.0 | 59 | Chemie (HOH) |
Sequence modifications
A, C: 3 - 317 (UniProt: Q9H3M7)
B, D: 1 - 105 (UniProt: P10599)
| PDB | External Database | Details |
|---|---|---|
| Ser 170 | Cys 170 | engineered mutation |
| Ser 205 | Cys 205 | engineered mutation |
| Ser 267 | Cys 267 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ala 35 | Cys 35 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 93511.8 | |
| All* | Total formula weight | 93511.8 |
