4LEM

Crystal structure of the Delta-pyrroline-5-carboxylate dehydrogenase from Mycobacterium tuberculosis

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	1-pyrroline-5-carboxylate dehydrogenase	polymer	563	61210.7	6	UniProt (O50443) Pfam (PF00171)	Mycobacterium tuberculosis
2	G, H, I, K (A, B, C, D)	COBALAMIN	non-polymer		1330.4	4	Chemie (B12)
3	J, L, M (C, D, F)	MAGNESIUM ION	non-polymer		24.3	3	Chemie (MG)
4	N, O, P, Q, R... (A, B, C, D, E...)	water	water		18.0	2514	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F: 1 - 543 (UniProt: O50443)

PDB	External Database	Details
Met -19	-	expression tag
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag
Asp 505	Gly 505	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	367264.1
Non-Polymers*	Number of molecules	7
	Total formula weight	5394.3
All*	Total formula weight	372658.5

*Water molecules are not included.