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4LEM

Crystal structure of the Delta-pyrroline-5-carboxylate dehydrogenase from Mycobacterium tuberculosis

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0003842molecular_function1-pyrroline-5-carboxylate dehydrogenase activity
A0006560biological_processproline metabolic process
A0009898cellular_componentcytoplasmic side of plasma membrane
A0010133biological_processproline catabolic process to glutamate
A0016491molecular_functionoxidoreductase activity
A0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
A0046872molecular_functionmetal ion binding
B0000166molecular_functionnucleotide binding
B0003842molecular_function1-pyrroline-5-carboxylate dehydrogenase activity
B0006560biological_processproline metabolic process
B0009898cellular_componentcytoplasmic side of plasma membrane
B0010133biological_processproline catabolic process to glutamate
B0016491molecular_functionoxidoreductase activity
B0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B0046872molecular_functionmetal ion binding
C0000166molecular_functionnucleotide binding
C0003842molecular_function1-pyrroline-5-carboxylate dehydrogenase activity
C0006560biological_processproline metabolic process
C0009898cellular_componentcytoplasmic side of plasma membrane
C0010133biological_processproline catabolic process to glutamate
C0016491molecular_functionoxidoreductase activity
C0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
C0046872molecular_functionmetal ion binding
D0000166molecular_functionnucleotide binding
D0003842molecular_function1-pyrroline-5-carboxylate dehydrogenase activity
D0006560biological_processproline metabolic process
D0009898cellular_componentcytoplasmic side of plasma membrane
D0010133biological_processproline catabolic process to glutamate
D0016491molecular_functionoxidoreductase activity
D0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
D0046872molecular_functionmetal ion binding
E0000166molecular_functionnucleotide binding
E0003842molecular_function1-pyrroline-5-carboxylate dehydrogenase activity
E0006560biological_processproline metabolic process
E0009898cellular_componentcytoplasmic side of plasma membrane
E0010133biological_processproline catabolic process to glutamate
E0016491molecular_functionoxidoreductase activity
E0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
E0046872molecular_functionmetal ion binding
F0000166molecular_functionnucleotide binding
F0003842molecular_function1-pyrroline-5-carboxylate dehydrogenase activity
F0006560biological_processproline metabolic process
F0009898cellular_componentcytoplasmic side of plasma membrane
F0010133biological_processproline catabolic process to glutamate
F0016491molecular_functionoxidoreductase activity
F0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
F0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues27
DetailsBINDING SITE FOR RESIDUE B12 A 601
ChainResidue
APHE246
AHOH737
AHOH738
AHOH769
AHOH773
AHOH792
AHOH887
AHOH912
AHOH969
AHOH1066
AHOH1068
AASP250
AHOH1082
AHOH1108
AHOH1180
CGLU383
CLYS386
CGLU398
CTYR399
CHOH844
AALA268
ATHR269
AHIS272
AARG373
AHOH709
AHOH711
AHOH720

site_idAC2
Number of Residues18
DetailsBINDING SITE FOR RESIDUE B12 B 601
ChainResidue
BPHE246
BASP250
BALA268
BTHR269
BHIS272
BARG373
BHOH706
BHOH735
BHOH791
BHOH830
BHOH841
BHOH870
BHOH986
BHOH1123
BHOH1148
CASP37
CPRO39
CHOH829

site_idAC3
Number of Residues14
DetailsBINDING SITE FOR RESIDUE B12 C 601
ChainResidue
CILE186
CPHE246
CASP250
CTHR269
CHIS272
CHOH780
CHOH792
CHOH819
CHOH842
CHOH851
CHOH961
CHOH1106
DASN280
DARG283

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG C 602
ChainResidue
CALA385
CLYS386
CALA388
CVAL391

site_idAC5
Number of Residues24
DetailsBINDING SITE FOR RESIDUE B12 D 601
ChainResidue
CALA79
CASP250
CVAL251
CALA254
CHOH907
DILE186
DPHE246
DASP250
DTHR269
DHIS272
DHOH720
DHOH741
DHOH742
DHOH785
DHOH794
DHOH809
DHOH822
DHOH884
DHOH949
DHOH964
DHOH977
DHOH995
DHOH1023
DHOH1129

site_idAC6
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG D 602
ChainResidue
DALA385
DLYS386
DALA388
DVAL391
DHOH828

site_idAC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG F 601
ChainResidue
FALA385
FLYS386
FALA388
FVAL391
FHOH795

Functional Information from PROSITE/UniProt
site_idPS00070
Number of Residues12
DetailsALDEHYDE_DEHYDR_CYS Aldehyde dehydrogenases cysteine active site. FdYQGQKCSAVS
ChainResidueDetails
APHE320-SER331

site_idPS00687
Number of Residues8
DetailsALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. GETGGKDF
ChainResidueDetails
AGLY292-PHE299

219140

PDB entries from 2024-05-01

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