4LDL
Structure of beta2 adrenoceptor bound to hydroxybenzylisoproterenol and an engineered nanobody
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Lysozyme, Beta-2 adrenergic receptor | polymer | 469 | 53471.0 | 1 | UniProt (P00720) UniProt (P07550) Pfam (PF00959) Pfam (PF00001) In PDB | Enterobacteria phage T4 | Endolysin, Lysis protein, Muramidase, Beta-2 adrenoreceptor, Beta-2 adrenoceptor |
2 | B | Camelid Antibody Fragment | polymer | 120 | 12949.4 | 1 | Lama glama (llama) | ||
3 | A | 4-[(1R)-1-hydroxy-2-{[1-(4-hydroxyphenyl)-2-methylpropan-2-yl]amino}ethyl]benzene-1,2-diol | non-polymer | 317.4 | 1 | Chemie (XQC) | |||
4 | A | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
5 | A | (2S)-2,3-dihydroxypropyl (7Z)-tetradec-7-enoate | non-polymer | 300.4 | 1 | Chemie (1WV) | |||
6 | water | water | 18.0 | 2 | Chemie (HOH) |
Sequence modifications
A: 867 - 1026 (UniProt: P00720)
A: 1029 - 1263 (UniProt: P07550)
A: 1264 - 1348 (UniProt: P07550)
PDB | External Database | Details |
---|---|---|
Asp 852 | - | expression tag |
Tyr 853 | - | expression tag |
Lys 854 | - | expression tag |
Asp 855 | - | expression tag |
Asp 856 | - | expression tag |
Asp 857 | - | expression tag |
Asp 858 | - | expression tag |
Ala 859 | - | expression tag |
Glu 860 | - | expression tag |
Asn 861 | - | expression tag |
Leu 862 | - | expression tag |
Tyr 863 | - | expression tag |
Phe 864 | - | expression tag |
Gln 865 | - | expression tag |
Gly 866 | - | expression tag |
Thr 919 | Cys 54 | engineered mutation |
Ala 962 | Cys 97 | engineered mutation |
Ala 1027 | - | linker |
Ala 1028 | - | linker |
PDB | External Database | Details |
---|---|---|
Thr 1096 | Met 96 | engineered mutation |
Thr 1098 | Met 98 | engineered mutation |
Glu 1187 | Asn 187 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Ala 1265 | Cys 265 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 66420.4 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 640.8 | |
All* | Total formula weight | 67061.2 |