4LAX
Crystal Structure Analysis of FKBP52, Complex with FK506
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Peptidyl-prolyl cis-trans isomerase FKBP4 | polymer | 269 | 30671.6 | 1 | UniProt (Q02790) Pfam (PF00254) | Homo sapiens (human) | PPIase FKBP4, 52 kDa FK506-binding protein, 52 kDa FKBP, FKBP-52, 59 kDa immunophilin, p59, FK506-binding protein 4, FKBP-4, FKBP59, HSP-binding immunophilin, HBI, Immunophilin FKBP52, Rotamase |
| 2 | B (A) | 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN | non-polymer | 804.0 | 1 | Chemie (FK5) PubChem (23377000) PubChem (177746942) PubChem (23308325) PubChem (23581796) PubChem (24978521) PubChem (54611630) PubChem (57206900) PubChem (44294761) PubChem (44314852) PubChem (403209) PubChem (439492) PubChem (59042420) PubChem (59111253) PubChem (59112447) PubChem (59118415) PubChem (44575549) PubChem (59746606) PubChem (46783859) PubChem (59917266) PubChem (59918741) PubChem (60086106) PubChem (46781577) PubChem (66509027) PubChem (66672804) PubChem (49874294) PubChem (71296869) PubChem (71316759) PubChem (71668407) PubChem (73265325) PubChem (57417278) PubChem (57892354) PubChem (57910335) PubChem (58584114) PubChem (59032416) PubChem (58946030) PubChem (59141120) PubChem (59049316) PubChem (59974193) PubChem (59993548) PubChem (60035606) PubChem (66709866) PubChem (67340654) PubChem (67626881) PubChem (68219140) PubChem (68712665) PubChem (69247758) PubChem (176478128) PubChem (89068341) PubChem (176856280) PubChem (177675132) PubChem (5372) PubChem (64779) PubChem (445643) PubChem (77906388) PubChem (89249909) PubChem (89545901) PubChem (89960652) PubChem (5353987) PubChem (145857191) PubChem (117646237) PubChem (6426916) PubChem (6436007) PubChem (6473866) PubChem (123552884) PubChem (5472317) PubChem (9832283) PubChem (9853905) PubChem (125039862) PubChem (9918805) PubChem (125136698) PubChem (125136697) PubChem (9963169) PubChem (129009965) PubChem (129010422) PubChem (130330191) PubChem (131676819) PubChem (6536850) PubChem (6610362) PubChem (6912836) PubChem (133562888) PubChem (133688365) PubChem (11556866) PubChem (134694629) PubChem (9940643) PubChem (12134936) PubChem (13006299) PubChem (137705868) PubChem (138106951) PubChem (138574020) PubChem (124511204) PubChem (140494820) PubChem (13819070) PubChem (140647114) PubChem (13819074) PubChem (13819069) PubChem (140893615) PubChem (13819073) PubChem (149048732) PubChem (125039860) PubChem (125039861) PubChem (125136699) PubChem (125136700) PubChem (160433486) PubChem (162711219) PubChem (163027397) PubChem (163027399) PubChem (163027400) PubChem (125182986) PubChem (126687738) PubChem (166023667) PubChem (168312998) PubChem (170277719) PubChem (171042252) PubChem (171360199) PubChem (172042935) PubChem (173882479) PubChem (129606865) PubChem (131668141) PubChem (137546410) PubChem (137546581) PubChem (138574025) PubChem (139032034) PubChem (140652196) PubChem (143265740) PubChem (144640477) PubChem (146323807) PubChem (156417380) PubChem (156528350) PubChem (160433487) PubChem (163027398) PubChem (163027401) PubChem (163027402) PubChem (167413568) PubChem (170997009) PubChem (171122179) PubChem (171137683) PubChem (171156312) PubChem (171322980) PubChem (171329370) PubChem (172634670) PubChem (175667550) | |||
| 3 | C, D, E (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 3 | Chemie (DMS) PubChem (679) | |||
| 4 | F (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) PubChem (753) | |||
| 5 | G (A) | water | water | 18.0 | 96 | Chemie (HOH) |
Sequence modifications
A: 16 - 260 (UniProt: Q02790)
| PDB | External Database | Details |
|---|---|---|
| Met -8 | - | expression tag |
| Ser -7 | - | expression tag |
| Tyr -6 | - | expression tag |
| Tyr -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| His -1 | - | expression tag |
| His 0 | - | expression tag |
| His 1 | - | expression tag |
| Asp 2 | - | expression tag |
| Tyr 3 | - | expression tag |
| Asp 4 | - | expression tag |
| Ile 5 | - | expression tag |
| Pro 6 | - | expression tag |
| Thr 7 | - | expression tag |
| Thr 8 | - | expression tag |
| Glu 9 | - | expression tag |
| Asn 10 | - | expression tag |
| Leu 11 | - | expression tag |
| Tyr 12 | - | expression tag |
| Phe 13 | - | expression tag |
| Gln 14 | - | expression tag |
| Gly 15 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 30671.6 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1130.5 | |
| All* | Total formula weight | 31802.1 |
