4LAX
Crystal Structure Analysis of FKBP52, Complex with FK506
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Peptidyl-prolyl cis-trans isomerase FKBP4 | polymer | 269 | 30671.6 | 1 | UniProt (Q02790) Pfam (PF00254) | Homo sapiens (human) | PPIase FKBP4, 52 kDa FK506-binding protein, 52 kDa FKBP, FKBP-52, 59 kDa immunophilin, p59, FK506-binding protein 4, FKBP-4, FKBP59, HSP-binding immunophilin, HBI, Immunophilin FKBP52, Rotamase |
| 2 | B (A) | 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN | non-polymer | 804.0 | 1 | Chemie (FK5) | |||
| 3 | C, D, E (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 3 | Chemie (DMS) | |||
| 4 | F (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | G (A) | water | water | 18.0 | 96 | Chemie (HOH) |
Sequence modifications
A: 16 - 260 (UniProt: Q02790)
| PDB | External Database | Details |
|---|---|---|
| Met -8 | - | expression tag |
| Ser -7 | - | expression tag |
| Tyr -6 | - | expression tag |
| Tyr -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| His -1 | - | expression tag |
| His 0 | - | expression tag |
| His 1 | - | expression tag |
| Asp 2 | - | expression tag |
| Tyr 3 | - | expression tag |
| Asp 4 | - | expression tag |
| Ile 5 | - | expression tag |
| Pro 6 | - | expression tag |
| Thr 7 | - | expression tag |
| Thr 8 | - | expression tag |
| Glu 9 | - | expression tag |
| Asn 10 | - | expression tag |
| Leu 11 | - | expression tag |
| Tyr 12 | - | expression tag |
| Phe 13 | - | expression tag |
| Gln 14 | - | expression tag |
| Gly 15 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 30671.6 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1130.5 | |
| All* | Total formula weight | 31802.1 |
