4LAX

Crystal Structure Analysis of FKBP52, Complex with FK506

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Peptidyl-prolyl cis-trans isomerase FKBP4	polymer	269	30671.6	1	UniProt (Q02790) Pfam (PF00254) In PDB	Homo sapiens (human)	PPIase FKBP4, 52 kDa FK506-binding protein, 52 kDa FKBP, FKBP-52, 59 kDa immunophilin, p59, FK506-binding protein 4, FKBP-4, FKBP59, HSP-binding immunophilin, HBI, Immunophilin FKBP52, Rotamase
2	A	8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN	non-polymer		804.0	1	Chemie (FK5)
3	A	DIMETHYL SULFOXIDE	non-polymer		78.1	3	Chemie (DMS)
4	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
5		water	water		18.0	96	Chemie (HOH)

Sequence modifications

A: 16 - 260 (UniProt: Q02790)

PDB	External Database	Details
Met -8	-	expression tag
Ser -7	-	expression tag
Tyr -6	-	expression tag
Tyr -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag
Asp 2	-	expression tag
Tyr 3	-	expression tag
Asp 4	-	expression tag
Ile 5	-	expression tag
Pro 6	-	expression tag
Thr 7	-	expression tag
Thr 8	-	expression tag
Glu 9	-	expression tag
Asn 10	-	expression tag
Leu 11	-	expression tag
Tyr 12	-	expression tag
Phe 13	-	expression tag
Gln 14	-	expression tag
Gly 15	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	30671.6
Non-Polymers*	Number of molecules	5
	Total formula weight	1130.5
All*	Total formula weight	31802.1

*Water molecules are not included.