4LAX

Crystal Structure Analysis of FKBP52, Complex with FK506

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE FK5 A 301

Chain	Residue
A	TYR57
A	TYR113
A	LYS121
A	PHE130
A	DMS302
A	PHE67
A	ASP68
A	PHE77
A	GLU85
A	VAL86
A	ILE87
A	TRP90
A	ALA112

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS A 302

Chain	Residue
A	GLU110
A	ALA112
A	TYR113
A	GLY114
A	FK5301

---

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE DMS A 303

Chain	Residue
A	LEU182

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS A 304

Chain	Residue
A	GLU166
A	GLY193
A	TYR202
A	ARG206
A	GLN209

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 305

Chain	Residue
A	TYR178
A	LYS181
A	GLN236
A	HOH461

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	88
Details	Domain: {"description":"PPIase FKBP-type 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00277","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	86
Details	Domain: {"description":"PPIase FKBP-type 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00277","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine; by CK2","evidences":[{"source":"UniProtKB","id":"P27124","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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