4L7F
Co-crystal Structure of JNK1 and AX13587
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mitogen-activated protein kinase 8 | polymer | 367 | 42377.1 | 1 | UniProt (P45983) Pfam (PF00069) | Homo sapiens (human) | MAP kinase 8, MAPK 8, JNK-46, Stress-activated protein kinase 1c, SAPK1c, Stress-activated protein kinase JNK1, c-Jun N-terminal kinase 1 |
| 2 | B (A) | N-[1-(4-fluorophenyl)cyclopropyl]-4-[(trans-4-hydroxycyclohexyl)amino]imidazo[1,2-a]quinoxaline-8-carboxamide | non-polymer | 459.5 | 1 | Chemie (1V5) | |||
| 3 | C (A) | water | water | 18.0 | 449 | Chemie (HOH) |
Sequence modifications
A: 7 - 362 (UniProt: P45983)
| PDB | External Database | Details |
|---|---|---|
| Ser 5 | - | expression tag |
| Leu 6 | - | expression tag |
| Trp 363 | - | expression tag |
| Arg 364 | - | expression tag |
| Lys 365 | - | expression tag |
| Gly 366 | - | expression tag |
| Ile 367 | - | expression tag |
| Ile 368 | - | expression tag |
| Thr 369 | - | expression tag |
| Ile 370 | - | expression tag |
| Thr 371 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 42377.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 459.5 | |
| All* | Total formula weight | 42836.6 |
