4L42
Crystal structures of human p70S6K1-PIF
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | RPS6KB1 protein | polymer | 346 | 39372.3 | 1 | UniProt (Q7Z721) Pfam (PF00069) Pfam (PF00433) UniProt (by SIFTS) (P23443) In PDB | Homo sapiens (human) | Ribosomal protein S6 kinase beta-1, Ribosomal protein S6 kinase, 70kDa, polypeptide 1, isoform CRA_c |
| 2 | A | 2-{[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl}-5-(trifluoromethyl)-1H-benzimidazole | non-polymer | 390.4 | 1 | Chemie (5FI) | |||
| 3 | A | SULFATE ION | non-polymer | 96.1 | 7 | Chemie (SO4) | |||
| 4 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 5 | water | water | 18.0 | 12 | Chemie (HOH) |
Sequence modifications
A: 52 - 394 (UniProt: Q7Z721)
| PDB | External Database | Details |
|---|---|---|
| Gly 49 | - | expression tag |
| Ala 50 | - | expression tag |
| Met 51 | - | expression tag |
| Glu 380 | Ser 403 | engineered mutation |
| Glu 381 | Ala 404 | engineered mutation |
| Gln 382 | Asn 405 | engineered mutation |
| Glu 383 | Gln 406 | engineered mutation |
| Met 384 | Val 407 | engineered mutation |
| Arg 386 | Leu 409 | engineered mutation |
| Asp 387 | Gly 410 | engineered mutation |
| Glu 389 | Thr 412 | engineered mutation |
| Ile 391 | Val 414 | engineered mutation |
| Asp 393 | Pro 416 | engineered mutation |
| Trp 394 | Ser 417 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 39372.3 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1128.3 | |
| All* | Total formula weight | 40500.6 |
