4L2H

Structure of a catalytically inactive PARG in complex with a poly-ADP-ribose fragment

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Poly(ADP-ribose) glycohydrolase	polymer	477	55885.0	1	UniProt (I6L8L7) Pfam (PF20811) Pfam (PF05028) In PDB	Tetrahymena thermophila
2	A	[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE	non-polymer		559.3	2	Chemie (AR6)
3		water	water		18.0	462	Chemie (HOH)

Sequence modifications

A: 1 - 457 (UniProt: I6L8L7)

PDB	External Database	Details
Met -19	-	expression tag
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag
Gln 256	Glu 256	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	55885.0
Non-Polymers*	Number of molecules	2
	Total formula weight	1118.6
All*	Total formula weight	57003.7

*Water molecules are not included.