4KXY
Human transketolase in complex with ThDP analogue (R)-2-(1,2-dihydroxyethyl)-3-deaza-ThDP
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Transketolase | polymer | 637 | 69647.5 | 2 | UniProt (P29401) Pfam (PF00456) Pfam (PF02779) Pfam (PF02780) In PDB | Homo sapiens (human) | TK |
2 | B, A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 27 | Chemie (EDO) | |||
3 | B, A | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
4 | B, A | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
5 | A, B | 2-{4-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-[(1R)-1,2-dihydroxyethyl]-3-methylthiophen-2-yl}ethyl trihydrogen diphosphate | non-polymer | 483.4 | 2 | Chemie (1U0) | |||
6 | B, A | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
7 | water | water | 18.0 | 1462 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 623 (UniProt: P29401)
PDB | External Database | Details |
---|---|---|
Leu 624 | - | expression tag |
Val 625 | - | expression tag |
Pro 626 | - | expression tag |
Arg 627 | - | expression tag |
Gly 628 | - | expression tag |
Ser 629 | - | expression tag |
Leu 630 | - | expression tag |
Glu 631 | - | expression tag |
His 632 | - | expression tag |
His 633 | - | expression tag |
His 634 | - | expression tag |
His 635 | - | expression tag |
His 636 | - | expression tag |
His 637 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 139294.9 | |
Non-Polymers* | Number of molecules | 35 |
Total formula weight | 2960.8 | |
All* | Total formula weight | 142255.8 |