4KXY

Human transketolase in complex with ThDP analogue (R)-2-(1,2-dihydroxyethyl)-3-deaza-ThDP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Transketolase	polymer	637	69647.5	2	UniProt (P29401) Pfam (PF00456) Pfam (PF02779) Pfam (PF02780)	Homo sapiens (human)	TK
2	BA, C, CA, D, DA... (B, A)	1,2-ETHANEDIOL	non-polymer		62.1	27	Chemie (EDO)
3	AA, I (B, A)	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)
4	HA, J (B, A)	SODIUM ION	non-polymer		23.0	2	Chemie (NA)
5	K, Z (A, B)	2-{4-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-[(1R)-1,2-dihydroxyethyl]-3-methylthiophen-2-yl}ethyl trihydrogen diphosphate	non-polymer		483.4	2	Chemie (1U0)
6	GA, R (B, A)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
7	LA, MA (A, B)	water	water		18.0	1462	Chemie (HOH)

Sequence modifications

A, B: 1 - 623 (UniProt: P29401)

PDB	External Database	Details
Leu 624	-	expression tag
Val 625	-	expression tag
Pro 626	-	expression tag
Arg 627	-	expression tag
Gly 628	-	expression tag
Ser 629	-	expression tag
Leu 630	-	expression tag
Glu 631	-	expression tag
His 632	-	expression tag
His 633	-	expression tag
His 634	-	expression tag
His 635	-	expression tag
His 636	-	expression tag
His 637	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	139294.9
Non-Polymers*	Number of molecules	35
	Total formula weight	2960.8
All*	Total formula weight	142255.8

*Water molecules are not included.